Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores
Abstract
Purpose
Materials and Methods
Results
Conclusion
Accompanying Article
Introduction
Materials and Methods
Samples
Genotyping and Quality Control
Statistical Methods
Association Analyses.
Polygenic Risk Scores.
Selection of SNPs Included in PRSs and Weights.
Breast Cancer PRSs.
Prostate Cancer PRS.
Results
Breast Cancer PRSs
Prostate Cancer PRS
Discriminatory Ability
Predicted Risks of Male Breast and Prostate Cancer by PRS Percentile
Discussion
Acknowledgment
Data Supplement
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Authors' Disclosures of Potential Conflicts of Interest
Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores
Julie Lecarpentier
Valentina Silvestri
Karoline B. Kuchenbaecker
Daniel Barrowdale
Joe Dennis
Lesley McGuffog
Penny Soucy
Goska Leslie
Piera Rizzolo
Anna Sara Navazio
Virginia Valentini
Veronica Zelli
Andrew Lee
Ali Amin Al Olama
Jonathan P. Tyrer
Melissa Southey
Esther M. John
Thomas A. Conner
David E. Goldgar
Saundra S. Buys
Ramunas Janavicius
Linda Steele
Yuan Chun Ding
Susan L. Neuhausen
Thomas V.O. Hansen
Ana Osorio
Jeffrey N. Weitzel
Angela Toss
Veronica Medici
Laura Cortesi
Ines Zanna
Domenico Palli
Paolo Radice
Siranoush Manoukian
Bernard Peissel
Jacopo Azzollini
Alessandra Viel
Giulia Cini
Giuseppe Damante
Stefania Tommasi
Paolo Peterlongo
Florentia Fostira
Ute Hamann
D. Gareth Evans
Alex Henderson
Carole Brewer
Diana Eccles
Jackie Cook
Kai-ren Ong
Lisa Walker
Lucy E. Side
Mary E. Porteous
Rosemarie Davidson
Shirley Hodgson
Debra Frost
Julian Adlard
Louise Izatt
Ros Eeles
Steve Ellis
Marc Tischkowitz
Andrew K. Godwin
Alfons Meindl
Andrea Gehrig
Bernd Dworniczak
Christian Sutter
Christoph Engel
Dieter Niederacher
Doris Steinemann
Eric Hahnen
Jan Hauke
Kerstin Rhiem
Karin Kast
Norbert Arnold
Nina Ditsch
Shan Wang-Gohrke
Barbara Wappenschmidt
Dorothea Wand
Christine Lasset
Dominique Stoppa-Lyonnet
Muriel Belotti
Francesca Damiola
Laure Barjhoux
Sylvie Mazoyer
Mattias Van Heetvelde
Bruce Poppe
Kim De Leeneer
Kathleen B.M. Claes
Miguel de la Hoya
Vanesa Garcia-Barberan
Trinidad Caldes
Pedro Perez Segura
Johanna I. Kiiski
Kristiina Aittomäki
Sofia Khan
Heli Nevanlinna
Christi J. van Asperen
Tibor Vaszko
Miklos Kasler
Edith Olah
Judith Balmaña
Sara Gutiérrez-Enríquez
Orland Diez
Alex Teulé
Angel Izquierdo
Esther Darder
Joan Brunet
Jesús Del Valle
Lidia Feliubadalo
Miquel Angel Pujana
Conxi Lazaro
Adalgeir Arason
Bjarni A. Agnarsson
Oskar Th. Johannsson
Rosa B. Barkardottir
Elisa Alducci
Silvia Tognazzo
Marco Montagna
Manuel R. Teixeira
Pedro Pinto
Amanda B. Spurdle
Helene Holland
Jong Won Lee
Min Hyuk Lee
Jihyoun Lee
Sung-Won Kim
Eunyoung Kang
Zisun Kim
Priyanka Sharma
Timothy R. Rebbeck
Joseph Vijai
Mark Robson
Anne Lincoln
Jacob Musinsky
Pragna Gaddam
Yen Y. Tan
Andreas Berger
Christian F. Singer
Jennifer T. Loud
Mark H. Greene
Anna Marie Mulligan
Gord Glendon
Irene L. Andrulis
Amanda Ewart Toland
Leigha Senter
Anders Bojesen
Henriette Roed Nielsen
Anne-Bine Skytte
Lone Sunde
Uffe Birk Jensen
Inge Sokilde Pedersen
Lotte Krogh
Torben A. Kruse
Maria A. Caligo
Sook-Yee Yoon
Soo-Hwang Teo
Anna von Wachenfeldt
Dezheng Huo
Sarah M. Nielsen
Olufunmilayo I. Olopade
Katherine L. Nathanson
Susan M. Domchek
Christa Lorenchick
Rachel C. Jankowitz
Ian Campbell
Paul James
Gillian Mitchell
Nick Orr
Sue Kyung Park
Mads Thomassen
Kenneth Offit
Fergus J. Couch
Jacques Simard
Douglas F. Easton
Georgia Chenevix-Trench
Rita K. Schmutzler
Antonis C. Antoniou
Laura Ottini
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