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Erschienen in: Annals of Surgical Oncology 2/2005

01.02.2005

Prospective Evaluation of Quality of Life of Patients Receiving Either Abdominoperineal Resection or Sphincter-Preserving Procedure for Rectal Cancer

verfasst von: Christian E. Schmidt, MD, MPH, Beate Bestmann, MA, Thomas Küchler, PhD, Walter E. Longo, MD, MBA, Bernd Kremer, MD, PhD

Erschienen in: Annals of Surgical Oncology | Ausgabe 2/2005

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Abstract

Background

Study results on quality of life (QoL) between patients receiving an anterior resection (AR) or abdominoperineal resection (APR) for rectal cancer vary greatly. A main reason is grounded in unequal methodology. The aims of this study were to assess differences in perceived QoL over time among patients treated with AR or APR with a recommended study design and methodology.

Methods

In a prospective study, the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire C30 and a tumor-specific module were administered to patients with rectal cancer before surgery, at discharge, and 3, 6, and 12 months after the operation. Comparisons were made between patients receiving an AR and those receiving an APR.

Results

Two hundred forty-nine patients were included; 46 patients received an APR and 203 an AR. QoL data were available for 212 patients, of which 112 were female and 100 male. No differences in the distribution of age, sex, or tumor stage were observed between groups. EORTC function scales showed no significant differences, including body image scales, between patients receiving an AR and those receiving an APR. In symptom scores, AR patients had more difficulty with diarrhea and constipation, whereas patients with APR experienced more impaired sexuality and pain in the anoperineal region. At discharge, patients receiving an AR were more confident about their future.

Conclusions

QoL in patients receiving an AR and those receiving an APR is not different. Although patients with APR experience more impaired sexuality, patients receiving an AR experience decreases in QoL because of impaired bowel function.
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Metadaten
Titel
Prospective Evaluation of Quality of Life of Patients Receiving Either Abdominoperineal Resection or Sphincter-Preserving Procedure for Rectal Cancer
verfasst von
Christian E. Schmidt, MD, MPH
Beate Bestmann, MA
Thomas Küchler, PhD
Walter E. Longo, MD, MBA
Bernd Kremer, MD, PhD
Publikationsdatum
01.02.2005
Erschienen in
Annals of Surgical Oncology / Ausgabe 2/2005
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/ASO.2005.12.036

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