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Toxicity and Quality of Life after Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy

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Abstract

Background

The purpose of our study was to determine the toxicity and quality of life for patients with peritoneal metastases after cytoreductive surgery (CS) plus hyperthermic intraperitoneal chemotherapy (HIPC).

Methods

From 2001 to 2005, 35 consecutive patients with peritoneal metastases enrolled in a prospective trial approved by the University of Minnesota Institutional Review Board. Their primary cancer sites included the appendix (19 patients), colon (7), mesothelioma (3), stomach (2), small bowel (2), gallbladder (1), and unknown (1). We performed CS in an effort to remove all or nearly all peritoneal tumor nodules. Using a closed technique, we administered hyperthermic mitomycin C into the peritoneal cavity for 90 min. Before treatment and then at 4-month postoperative intervals, we used the functional assessment of cancer therapy-colon subscale (FACT-C) instrument to assess the patients’ quality of life.

Results

The median hospital stay was 9 days; 12 patients were hospitalized at least 30 days or required readmission within 30 days after treatment. The postoperative mortality rate was 0%; adverse events occurred in 18 (51%) patients. As of December 2005, 20 patients were alive; 14 had died of progressive disease and 1 of an unrelated cause. The median survival time was 21.4 months. Quality of life measurements, including trial outcome index (TOI), FACT-colon, and FACT-general, returned to baseline 4 months after treatment and were significantly improved at 8 and 12 months.

Conclusions

Despite early toxicity, CS plus HIPC may prolong the overall survival rate of patients with peritoneal metastases and improve quality of life measurements.

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Acknowledgments

The authors wish to thank Mary E. Knatterud, Ph.D. for her editorial assistance in preparing this paper.

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Authors and Affiliations

  1. Division of Surgical Oncology, University of Minnesota Medical Center, 420 Delaware Street SE, Minneapolis, MN, 55455, USA

    Todd M. Tuttle MD, MS & Amy Knutsen MD

  2. Biostatistics Core, University of Minnesota Cancer Center, 420 Delaware Street SE, Minneapolis, MN, 55455, USA

    Yan Zhang MS

  3. Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN, USA

    Edward Greeno MD

Authors
  1. Todd M. Tuttle MD, MS
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  2. Yan Zhang MS
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  3. Edward Greeno MD
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  4. Amy Knutsen MD
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Corresponding author

Correspondence to Todd M. Tuttle MD, MS.

Additional information

Source of support: University of Minnesota Cancer Center. This original work was originally presented at the 2006 Gastrointestinal Cancer Symposium.

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Tuttle, T.M., Zhang, Y., Greeno, E. et al. Toxicity and Quality of Life after Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol 13, 1627–1632 (2006). https://doi.org/10.1245/s10434-006-9186-6

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  • DOI: https://doi.org/10.1245/s10434-006-9186-6

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