Erschienen in:
01.05.2007 | Editorial
Surgical Management of Familial Hyperparathyroidism
verfasst von:
Douglas B. Evans, M.D., Thereasa A. Rich, M.S., Gilbert J. Cote, Ph.D.
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 5/2007
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Excerpt
In the February 2007 issue of the journal, the members of the Section of Endocrine Surgery at the University of Wisconsin under the leadership of Dr. Herb Chen report their experience with radioguided parathyroidectomy in 19 patients with familial hyperparathyroidism (HPT).
1 The cause of HPT was multiple endocrine neoplasia type 1 (MEN1) in 11 patients, multiple endocrine neoplasia type 2 (MEN2) in 1, and presumed nonsyndromic or familial isolated HPT (FIHPT) in 7. The gamma probe accurately localized all hyperplastic parathyroid glands and when combined with the intraoperative parathyroid hormone (IOPTH) assay resulted in the correction of hypercalcemia (at least in the short term) in all 19 patients. Such excellent results require accurate intraoperative identification of the parathyroid glands, including those that may exist in ectopic locations, as well as a thorough understanding of the natural history of the familial syndromes associated with HPT to allow for the proper management of the parathyroids once they are identified. Finding the parathyroid glands is of value only if one knows how many to remove, when to cryopreserve, and when and where to autograft; the gamma probe is just one piece of the puzzle necessary to generate the results as seen from the University of Wisconsin. …
