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Appraisal of 1 cm Hepatectomy Margins for Intrahepatic Micrometastases in Patients with Colorectal Carcinoma Liver Metastasis

  • Hepatic and Pancreatic Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

This study sought to clarify the distribution of intrahepatic micrometastases and elucidate an adequate hepatectomy margin for colorectal carcinoma liver metastases.

Methods

Intrahepatic micrometastases in resected specimens from 90 patients who underwent hepatectomy for colorectal carcinoma liver metastases were examined retrospectively. Intrahepatic micrometastases were defined as microscopic lesions spatially separated from the gross tumor. Distances from these lesions to the hepatic tumor borders were measured histologically, and the density of intrahepatic micrometastases (number of lesions/mm2) calculated relative to the advancing tumor border in a zone <1 cm from the border (close) or ≥1 cm away (distant). Median follow-up time was 127 months.

Results

A total of 294 intrahepatic micrometastases were detected in 52 (58%) patients; 95% of these occurred in the close zone. The density of intrahepatic micrometastases was significantly higher in the close zone (mean 74.8 × 10−4  lesions/mm2) than in the distant zone (mean 7.4 × 10−4  lesions/mm2; P < 0.001). Hepatectomy margin status was positive by 0 cm in 10 patients or negative by <1 cm in 51, and by ≥1 cm in 29 patients. The median survival times were 18, 33, and 89 months in patients with hepatectomy margins 0 cm, <1 cm, and ≥1 cm, respectively. Hepatectomy margin status independently influenced survival (P < 0.001) and disease-free survival (P < 0.001).

Conclusion

The currently recommended ≥1 cm hepatectomy margin should remain the goal for resections of colorectal carcinoma liver metastases, based on the distribution of intrahepatic micrometastases and survival risk.

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Authors and Affiliations

  1. Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata City, 951-8510, Japan

    Toshifumi Wakai MD, PhD, Yoshio Shirai MD, PhD, Jun Sakata MD, PhD, Vladimir A. Valera MD, PhD, Pavel V. Korita MD & Katsuyoshi Hatakeyama MD, PhD, FACS

  2. Department of Medical Informatics, Niigata University Medical and Dental Hospital, 1-754 Asahimachi-dori, Chuo-ku, Niigata City, 951-8520, Japan

    Kouhei Akazawa PhD

  3. Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata City, 951-8510, Japan

    Yoichi Ajioka MD, PhD

Authors
  1. Toshifumi Wakai MD, PhD
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  2. Yoshio Shirai MD, PhD
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  3. Jun Sakata MD, PhD
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  4. Vladimir A. Valera MD, PhD
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  5. Pavel V. Korita MD
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  6. Kouhei Akazawa PhD
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  7. Yoichi Ajioka MD, PhD
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  8. Katsuyoshi Hatakeyama MD, PhD, FACS
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Correspondence to Toshifumi Wakai MD, PhD.

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Wakai, T., Shirai, Y., Sakata, J. et al. Appraisal of 1 cm Hepatectomy Margins for Intrahepatic Micrometastases in Patients with Colorectal Carcinoma Liver Metastasis. Ann Surg Oncol 15, 2472–2481 (2008). https://doi.org/10.1245/s10434-008-0023-y

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  • DOI: https://doi.org/10.1245/s10434-008-0023-y

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