Skip to main content
Erschienen in: Annals of Surgical Oncology 6/2008

01.06.2008 | Gastrointestinal Oncology

Surgical Complications and the Risk Factors of Laparoscopy-Assisted Distal Gastrectomy in Early Gastric Cancer

verfasst von: Keun Won Ryu, MD, Young-Woo Kim, MD, Jun Ho Lee, MD, Byung-Ho Nam, PhD, Myeong-Cherl Kook, MD, Il Ju Choi, MD, Jae-Moon Bae, MD

Erschienen in: Annals of Surgical Oncology | Ausgabe 6/2008

Einloggen, um Zugang zu erhalten

Abstract

Background

Information on surgical complications of laparoscopy-assisted distal gastrectomy (LADG) and their risk factors is limited in the literature despite increasing popularity of this procedure. This study was performed to identify the surgical complications and their associated risk factors of LADG in early gastric cancer.

Methods

LADG was performed in 347 gastric cancer patients from January 2002 to December 2006 at the Korean National Cancer Center by four surgeons with ample experience of open gastric surgery before LADG. LADG indications for cases of gastric cancer at our institution are preoperatively diagnosed cT1N0 or cT1N1, except in cases with an absolute indication for endoscopic resection. Lymph node dissection of more than D1 + β was performed in all patients. Intraoperative and postoperative complications were reviewed and their risk factors were retrospectively analyzed by prospective database information.

Results

Forty complications occurred in 34 patients (9.8%), but there was no mortality. Intraoperative complications occurred in nine patients (2.6%), and open conversion was performed in eight (2.3%) of these patients. Early and late postoperative complications occurred in 21 (6.1%) and 10 (2.9%) patients, respectively. The most serious complication was vascular injury resulting in bleeding or organ ischemia, which occurred in seven patients. Degree of lymph node dissection and surgical inexperience were found to be risk factors of surgical complication (P = .023, odds ratio 2.832, 95% confidence interval 1.155–6.946 vs. P = .028, odds ratio 2.975, 95% confidence interval 1.127–7.854).

Conclusions

Lymph node dissection during LADG should be performed cautiously to prevent surgical complications like vascular injuries, especially during the surgeon’s early learning period.
Literatur
1.
Zurück zum Zitat Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55:74–108PubMedCrossRef Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55:74–108PubMedCrossRef
2.
Zurück zum Zitat Shin HR, Won YJ, Jung KW, et al. Nationwide cancer incidence in Korea, 1999–2001: first result using the national cancer incidence database. Cancer Res Treat 2005; 37:325–31CrossRef Shin HR, Won YJ, Jung KW, et al. Nationwide cancer incidence in Korea, 1999–2001: first result using the national cancer incidence database. Cancer Res Treat 2005; 37:325–31CrossRef
4.
Zurück zum Zitat Kim YW, Bae JM, Lee JH, et al. The role of hand-assisted laparoscopic distal gastrectomy for distal gastric cancer. Surg Endosc 2005;19:29–33PubMedCrossRef Kim YW, Bae JM, Lee JH, et al. The role of hand-assisted laparoscopic distal gastrectomy for distal gastric cancer. Surg Endosc 2005;19:29–33PubMedCrossRef
5.
Zurück zum Zitat Lee JH, Ryu KW, Doh YW, et al. Liver lift: a simple suture technique for liver retraction during laparoscopic gastric surgery. J Surg Oncol 2007;95:83–5PubMedCrossRef Lee JH, Ryu KW, Doh YW, et al. Liver lift: a simple suture technique for liver retraction during laparoscopic gastric surgery. J Surg Oncol 2007;95:83–5PubMedCrossRef
6.
Zurück zum Zitat Adachi Y, Suematsu T, Shiraishi N, et al. Quality of life after laparoscopy-assisted Billroth I gastrectomy. Ann Surg 1999;229:49–54PubMedCrossRef Adachi Y, Suematsu T, Shiraishi N, et al. Quality of life after laparoscopy-assisted Billroth I gastrectomy. Ann Surg 1999;229:49–54PubMedCrossRef
7.
Zurück zum Zitat Braga M, Vignali A, Zuliani W, et al. Laparoscopic versus open colorectal surgery: cost-benefit analysis in a single-center randomized trial. Ann Surg 2005;242:890–5PubMedCrossRef Braga M, Vignali A, Zuliani W, et al. Laparoscopic versus open colorectal surgery: cost-benefit analysis in a single-center randomized trial. Ann Surg 2005;242:890–5PubMedCrossRef
8.
Zurück zum Zitat Huscher CGS, Mingoli A, Sgarzini G, et al. Laparoscopic versus open subtotal gastrectomy for distal gastric cancer: five-year results of a randomized prospective trial. Ann Surg 2005;241:232–7PubMedCrossRef Huscher CGS, Mingoli A, Sgarzini G, et al. Laparoscopic versus open subtotal gastrectomy for distal gastric cancer: five-year results of a randomized prospective trial. Ann Surg 2005;241:232–7PubMedCrossRef
9.
Zurück zum Zitat Kitano S, Shiraishi N, Uyama I, et al. A multicenter study on oncologic outcome of laparoscopic gastrectomy for early gastric cancer in Japan. Ann Surg 2007;245:68–72PubMedCrossRef Kitano S, Shiraishi N, Uyama I, et al. A multicenter study on oncologic outcome of laparoscopic gastrectomy for early gastric cancer in Japan. Ann Surg 2007;245:68–72PubMedCrossRef
10.
Zurück zum Zitat Clinical Outcomes of Surgical Therapy Study Group. A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med 2004;350:2050–9CrossRef Clinical Outcomes of Surgical Therapy Study Group. A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med 2004;350:2050–9CrossRef
11.
Zurück zum Zitat Bonenkamp JJ, Songun I, Hermans J, et al. Randomised comparison of morbidity after D1 and D2 dissection for gastric cancer in 996 Dutch patients. Lancet 1995;345:745–8PubMedCrossRef Bonenkamp JJ, Songun I, Hermans J, et al. Randomised comparison of morbidity after D1 and D2 dissection for gastric cancer in 996 Dutch patients. Lancet 1995;345:745–8PubMedCrossRef
12.
Zurück zum Zitat Cuschieri A, Fayers P, Fielding J, et al. Postoperative morbidity and mortality after D1 and D2 resections for gastric cancer: preliminary results of the MRC randomized controlled surgical trial. Lancet 1996;347:995–9PubMedCrossRef Cuschieri A, Fayers P, Fielding J, et al. Postoperative morbidity and mortality after D1 and D2 resections for gastric cancer: preliminary results of the MRC randomized controlled surgical trial. Lancet 1996;347:995–9PubMedCrossRef
13.
Zurück zum Zitat Sano T, Sasako M, Yamamoto S, et al. Gastric cancer surgery: morbidity and mortality results from a prospective randomized controlled trial (JCOG9501) comparing D2 and extended para-aortic lymphadenectomy. Japan Clinical Oncology Group Study 9501. J Clin Oncol 2004;22:2767–73PubMedCrossRef Sano T, Sasako M, Yamamoto S, et al. Gastric cancer surgery: morbidity and mortality results from a prospective randomized controlled trial (JCOG9501) comparing D2 and extended para-aortic lymphadenectomy. Japan Clinical Oncology Group Study 9501. J Clin Oncol 2004;22:2767–73PubMedCrossRef
14.
Zurück zum Zitat Park DJ, Lee HJ, Kim HH, et al. Predictors of operative morbidity and mortality in gastric cancer surgery. Br J Surg 2005;92:1099–102PubMedCrossRef Park DJ, Lee HJ, Kim HH, et al. Predictors of operative morbidity and mortality in gastric cancer surgery. Br J Surg 2005;92:1099–102PubMedCrossRef
15.
Zurück zum Zitat Kodera Y, Sasako M, Yamamoto S, et al. Identification of risk factors for the development of complications following extended and superextended lymphadenectomies for gastric cancer. Br J Surg 2005;92:1103–9PubMedCrossRef Kodera Y, Sasako M, Yamamoto S, et al. Identification of risk factors for the development of complications following extended and superextended lymphadenectomies for gastric cancer. Br J Surg 2005;92:1103–9PubMedCrossRef
16.
Zurück zum Zitat Keats AS. The ASA classification of physical status—a recapitulation. Anesthesiology 1978;49:233–6PubMedCrossRef Keats AS. The ASA classification of physical status—a recapitulation. Anesthesiology 1978;49:233–6PubMedCrossRef
17.
Zurück zum Zitat Choi IJ, Kim CG, Chang HJ, et al. The learning curve for EMR with circumferential mucosal incision in treating intramucosal gastric neoplasm. Gastrointest Endosc 2005;62:860–5PubMedCrossRef Choi IJ, Kim CG, Chang HJ, et al. The learning curve for EMR with circumferential mucosal incision in treating intramucosal gastric neoplasm. Gastrointest Endosc 2005;62:860–5PubMedCrossRef
18.
Zurück zum Zitat Lee JH, Ryu KW, Lee JH, et al. Learning curve for total gastrectomy with D2 lymph node dissection: cumulative sum analysis for qualified surgery. Ann Surg Oncol 2006;13:1175–81PubMedCrossRef Lee JH, Ryu KW, Lee JH, et al. Learning curve for total gastrectomy with D2 lymph node dissection: cumulative sum analysis for qualified surgery. Ann Surg Oncol 2006;13:1175–81PubMedCrossRef
19.
Zurück zum Zitat Parikh D, Johnson M, Chagla L, et al. D2 gastrectomy: lessons from a prospective audit of the learning curve. Br J Surg 1996;83:1595–9PubMedCrossRef Parikh D, Johnson M, Chagla L, et al. D2 gastrectomy: lessons from a prospective audit of the learning curve. Br J Surg 1996;83:1595–9PubMedCrossRef
20.
21.
Zurück zum Zitat Ryu KW, Lee JH, Choi IJ, et al. Preoperative endoscopic clipping: localizing technique of early gastric cancer. J Surg Oncol 2003;82:75–7PubMedCrossRef Ryu KW, Lee JH, Choi IJ, et al. Preoperative endoscopic clipping: localizing technique of early gastric cancer. J Surg Oncol 2003;82:75–7PubMedCrossRef
22.
Zurück zum Zitat Choban PS, Flancbaum L. The impact of obesity on surgical outcomes: a review. J Am Coll Surg 1997;185:593–603PubMedCrossRef Choban PS, Flancbaum L. The impact of obesity on surgical outcomes: a review. J Am Coll Surg 1997;185:593–603PubMedCrossRef
23.
Zurück zum Zitat Bonenkamp JJ, van de Velde CJ, Kampschoer GH, et al. Comparison of factors influencing the prognosis of Japanese, German, and Dutch gastric cancer patients. World J Surg 1993;17:410–4PubMedCrossRef Bonenkamp JJ, van de Velde CJ, Kampschoer GH, et al. Comparison of factors influencing the prognosis of Japanese, German, and Dutch gastric cancer patients. World J Surg 1993;17:410–4PubMedCrossRef
24.
Zurück zum Zitat Kim MC, Jung GJ, Kim HH. Morbidity and mortality of laparoscopy-assisted gastrectomy with extraperigastric lymph node dissection for gastric cancer. Dig Dis Sci 2007;52:543–8PubMedCrossRef Kim MC, Jung GJ, Kim HH. Morbidity and mortality of laparoscopy-assisted gastrectomy with extraperigastric lymph node dissection for gastric cancer. Dig Dis Sci 2007;52:543–8PubMedCrossRef
25.
Zurück zum Zitat Kim MC, Choi HJ, Jung GJ, et al. Techniques and complication of laparoscopy assisted distal gastrectomy (LADG) for gastric cancer. Eur J Surg Oncol 2007;33:700–5PubMed Kim MC, Choi HJ, Jung GJ, et al. Techniques and complication of laparoscopy assisted distal gastrectomy (LADG) for gastric cancer. Eur J Surg Oncol 2007;33:700–5PubMed
26.
Zurück zum Zitat Perko Z, Pogorelic Z, Bilan K, et al. Lateral thermal damage to rat abdominal wall after harmonic scalpel application. Surg Endosc 2006;20:322–4PubMedCrossRef Perko Z, Pogorelic Z, Bilan K, et al. Lateral thermal damage to rat abdominal wall after harmonic scalpel application. Surg Endosc 2006;20:322–4PubMedCrossRef
27.
Zurück zum Zitat Kim MC, Jung GJ, Kim HH. Learning curve of laparoscopy-assisted distal gastrectomy with systemic lymphadenectomy for early gastric cancer. World J Gastroenterol 2005;11:7509–11 Kim MC, Jung GJ, Kim HH. Learning curve of laparoscopy-assisted distal gastrectomy with systemic lymphadenectomy for early gastric cancer. World J Gastroenterol 2005;11:7509–11
28.
Zurück zum Zitat Jin SH, Kim DY, Kim H, et al. Multidemensional learning curve in laparoscopy-assisted gastrectomy for early gastric cancer. Surg Endosc 2007;21:28–33PubMedCrossRef Jin SH, Kim DY, Kim H, et al. Multidemensional learning curve in laparoscopy-assisted gastrectomy for early gastric cancer. Surg Endosc 2007;21:28–33PubMedCrossRef
29.
Zurück zum Zitat Lee JH, Paik YH, Lee JS, et al. Abdominal shape of gastric cancer patients influences short-term surgical outcomes. Ann Surg Oncol 2007;14:1288–94PubMedCrossRef Lee JH, Paik YH, Lee JS, et al. Abdominal shape of gastric cancer patients influences short-term surgical outcomes. Ann Surg Oncol 2007;14:1288–94PubMedCrossRef
Metadaten
Titel
Surgical Complications and the Risk Factors of Laparoscopy-Assisted Distal Gastrectomy in Early Gastric Cancer
verfasst von
Keun Won Ryu, MD
Young-Woo Kim, MD
Jun Ho Lee, MD
Byung-Ho Nam, PhD
Myeong-Cherl Kook, MD
Il Ju Choi, MD
Jae-Moon Bae, MD
Publikationsdatum
01.06.2008
Verlag
Springer-Verlag
Erschienen in
Annals of Surgical Oncology / Ausgabe 6/2008
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-008-9845-x

Weitere Artikel der Ausgabe 6/2008

Annals of Surgical Oncology 6/2008 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.