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Erschienen in: Annals of Surgical Oncology 13/2013

01.12.2013 | Bone and Soft Tissue Sarcomas

Extrathoracic Location and “Borderline” Histology are Associated with Recurrence of Solitary Fibrous Tumors After Surgical Resection

verfasst von: Breelyn A. Wilky, MD, Elizabeth A. Montgomery, MD, Angela A. Guzzetta, MD, Nita Ahuja, MD, Christian F. Meyer, MD, PhD

Erschienen in: Annals of Surgical Oncology | Ausgabe 13/2013

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Abstract

Background

Most solitary fibrous tumors (SFTs) are cured by complete resection, but many recurrent and metastatic SFTs do not respond to treatment and are fatal. Malignant histology, defined by England’s pathologic criteria, is strongly associated with recurrence, but some benign SFTs still behave aggressively. Several studies have suggested that extrathoracic SFTs have a worse prognosis. We reviewed thoracic and extrathoracic SFTs from our institution to determine if extrathoracic location is associated with recurrence, independent of malignant histology.

Methods

With IRB approval, we retrieved patient pathology reports from the Johns Hopkins Surgical Pathology database between 1991 and 2011 and included 83 SFT patients in our analysis. Patient history and outcomes were obtained from the medical record and primary care physicians. Predictors of recurrence were analyzed by univariate and multivariate analysis and survival determined by the Kaplan–Meier method.

Results

Of the 83 patients, 59 had extrathoracic SFTs in neurologic (n = 24), extremity or head/neck (n = 13), or visceral/intraabdominal (n = 22) sites. A total of 74 SFTs were classified benign and 9 as malignant. Of the 14 recurrences, 13 occurred in extrathoracic SFTs; only 7 were classified as malignant. Multivariate analysis confirmed that malignant histology had the strongest association with recurrence, but extrathoracic location also independently predicted recurrence. A total of 20 benign SFTs possessed 1 or more of England’s criteria but to an insufficient degree for malignant classification. These “borderline” SFTs were more likely to recur than benign SFTs without these features.

Conclusions

Extrathoracic and “borderline” SFTs with any of England’s criteria have a higher risk of recurrence.
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Metadaten
Titel
Extrathoracic Location and “Borderline” Histology are Associated with Recurrence of Solitary Fibrous Tumors After Surgical Resection
verfasst von
Breelyn A. Wilky, MD
Elizabeth A. Montgomery, MD
Angela A. Guzzetta, MD
Nita Ahuja, MD
Christian F. Meyer, MD, PhD
Publikationsdatum
01.12.2013
Verlag
Springer US
Erschienen in
Annals of Surgical Oncology / Ausgabe 13/2013
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-013-3241-x

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