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Erschienen in: Annals of Surgical Oncology 3/2014

01.03.2014 | Endocrine Tumors

A Systematic Review and Meta-analysis Comparing Surgically-Related Complications between Robotic-Assisted Thyroidectomy and Conventional Open Thyroidectomy

verfasst von: Brian Hung-Hin Lang, MS, FRACS, Carlos K. H. Wong, PhD, Julian Shun Tsang, MBBS, MRCS, Kai Pun Wong, MBBS, FRCS, Koon Yat Wan, MBBS, FRCR

Erschienen in: Annals of Surgical Oncology | Ausgabe 3/2014

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Abstract

Background

Despite gaining popularity, robotic-assisted thyroidectomy (RT) remains controversial. This systematic review and meta-analysis is aimed at comparing surgically-related complications between RT and conventional open thyroidectomy (OT).

Methods

A systematic review of the literature was performed to identify studies comparing surgically-related outcomes between RT and OT. Studies that compared ≥1 surgically-related outcomes between RT and OT were included. Outcomes included operating time, blood loss, complications, and hospital stay. Meta-analysis was performed using a fixed-effects model.

Results

Eleven studies were eligible but none were randomized controlled trials. Of the 2,375 patients, 839 (35.3 %) underwent RT, while 1,536 (64.7 %) underwent OT. RT was significantly associated with longer operating time (p < 0.001), hospital stay (p = 0.023) and higher temporary recurrent laryngeal nerve (RLN) injury (p = 0.016). Although there was no correlation between the number of RTs reported in the study and the rate of temporary RLN injury (p = −0.486, p = 0.328, respectively), routine perioperative laryngoscopy was performed in only 2 of 11 studies. Blood loss (p = 0.485), temporary (p = 0.333) and permanent (p = 0.599) hypocalcemia, hematoma (p = 0.602), and overall morbidity (p = 0.880) appeared comparable. Two (0.2 %) brachial plexus injuries in RT were reported in one study.

Conclusions

Relative to OT, RT was associated with significantly longer operating time, longer hospital stay, and higher temporary RLN injury rate but comparable permanent complications and overall morbidity. Given some of the limitations with the literature and the potential added surgical risks and morbidity in RT, application of the robot in thyroid surgery should be carefully and thoroughly discussed before one decides on the procedure.
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Literatur
2.
Zurück zum Zitat Lang BH. Minimally invasive thyroid and parathyroid operations: surgical techniques and pearls. Adv Surg. 2010;44:185–198.PubMedCrossRef Lang BH. Minimally invasive thyroid and parathyroid operations: surgical techniques and pearls. Adv Surg. 2010;44:185–198.PubMedCrossRef
4.
Zurück zum Zitat Chung WY. Pros of robotic transaxillary thyroid surgery: its impact on cancer control and surgical quality. Thyroid. 2012;22(10):986–987.PubMedCrossRef Chung WY. Pros of robotic transaxillary thyroid surgery: its impact on cancer control and surgical quality. Thyroid. 2012;22(10):986–987.PubMedCrossRef
5.
Zurück zum Zitat Kang SW, Jeong JJ, Nam KH, Chang HS, Chung WY, Park CS. Robot-assisted endoscopic thyroidectomy for thyroid malignancies using a gasless transaxillary approach. J Am Coll Surg. 2009;209(2):e1–e7.PubMedCrossRef Kang SW, Jeong JJ, Nam KH, Chang HS, Chung WY, Park CS. Robot-assisted endoscopic thyroidectomy for thyroid malignancies using a gasless transaxillary approach. J Am Coll Surg. 2009;209(2):e1–e7.PubMedCrossRef
6.
Zurück zum Zitat Lewis CM, Chung WY, Holsinger FC. Feasibility and surgical approach of transaxillary robotic thyroidectomy without CO2 insufflation. Head Neck. 2010;32(1):121–126.PubMed Lewis CM, Chung WY, Holsinger FC. Feasibility and surgical approach of transaxillary robotic thyroidectomy without CO2 insufflation. Head Neck. 2010;32(1):121–126.PubMed
7.
Zurück zum Zitat Lang BHH, Chow MP. A comparison of surgical outcomes between endoscopic and robotically assisted thyroidectomy: the authors’ initial experience. Surg Endosc. 2011;25(5):1617–1623.PubMedCentralPubMedCrossRef Lang BHH, Chow MP. A comparison of surgical outcomes between endoscopic and robotically assisted thyroidectomy: the authors’ initial experience. Surg Endosc. 2011;25(5):1617–1623.PubMedCentralPubMedCrossRef
8.
Zurück zum Zitat Berber E, Heiden K, Akyildiz H, Milas M, Mitchell J, Siperstein A. Robotic transaxillary thyroidectomy: report of 2 cases and description of the technique. Surg Laparosc Endosc Percutan Tech. 2010;20(2):e60–e63.CrossRef Berber E, Heiden K, Akyildiz H, Milas M, Mitchell J, Siperstein A. Robotic transaxillary thyroidectomy: report of 2 cases and description of the technique. Surg Laparosc Endosc Percutan Tech. 2010;20(2):e60–e63.CrossRef
9.
Zurück zum Zitat Kandil E, Noureldine S, Abdel Khalek M, et al. Initial experience using robot- assisted transaxillary thyroidectomy for Graves’ disease. J Visc Surg. 2011;148(6):e447–e451.PubMedCrossRef Kandil E, Noureldine S, Abdel Khalek M, et al. Initial experience using robot- assisted transaxillary thyroidectomy for Graves’ disease. J Visc Surg. 2011;148(6):e447–e451.PubMedCrossRef
10.
Zurück zum Zitat Inabnet WB 3rd. Robotic thyroidectomy: must we drive a luxury sedan to arrive at our destination safely? Thyroid. 2012;22(10):988–990.PubMedCrossRef Inabnet WB 3rd. Robotic thyroidectomy: must we drive a luxury sedan to arrive at our destination safely? Thyroid. 2012;22(10):988–990.PubMedCrossRef
11.
Zurück zum Zitat Patel D, Kebebew E. Pros and cons of robotic transaxillary thyroidectomy. Thyroid. 2012;22(10):984–985.PubMedCrossRef Patel D, Kebebew E. Pros and cons of robotic transaxillary thyroidectomy. Thyroid. 2012;22(10):984–985.PubMedCrossRef
12.
Zurück zum Zitat Perrier ND. Why I have abandoned robot-assisted transaxillary thyroid surgery. Surgery. 2012;152(6):1025–1026.PubMedCrossRef Perrier ND. Why I have abandoned robot-assisted transaxillary thyroid surgery. Surgery. 2012;152(6):1025–1026.PubMedCrossRef
13.
14.
Zurück zum Zitat Jackson NR, Yao L, Tufano RP, Kandil EH. Safety of robotic thyroidectomy approaches: meta-analysis and systematic review. Head Neck. 2013. doi 10.1002/hed.23223. Jackson NR, Yao L, Tufano RP, Kandil EH. Safety of robotic thyroidectomy approaches: meta-analysis and systematic review. Head Neck. 2013. doi 10.​1002/​hed.​23223.
15.
Zurück zum Zitat Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.PubMedCentralPubMedCrossRef Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.PubMedCentralPubMedCrossRef
16.
Zurück zum Zitat Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088–1101.PubMedCrossRef Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088–1101.PubMedCrossRef
17.
Zurück zum Zitat Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–634.PubMedCrossRef Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–634.PubMedCrossRef
18.
Zurück zum Zitat Lee J, Nah KY, Kim RM, Ahn YH, Soh EY, Chung WY. Differences in postoperative outcomes, function, and cosmesis: open versus robotic thyroidectomy. Surg Endosc. 2010;24(12):3186–3194.PubMedCrossRef Lee J, Nah KY, Kim RM, Ahn YH, Soh EY, Chung WY. Differences in postoperative outcomes, function, and cosmesis: open versus robotic thyroidectomy. Surg Endosc. 2010;24(12):3186–3194.PubMedCrossRef
19.
Zurück zum Zitat Landry CS, Grubbs EG, Stephen Morris G, et al. Robot assisted transaxillary surgery (RATS) for the removal of thyroid and parathyroid glands. Surgery. 2011;149(4):549–555.PubMedCrossRef Landry CS, Grubbs EG, Stephen Morris G, et al. Robot assisted transaxillary surgery (RATS) for the removal of thyroid and parathyroid glands. Surgery. 2011;149(4):549–555.PubMedCrossRef
20.
Zurück zum Zitat Lee S, Ryu HR, Park JH, et al. Early surgical outcomes comparison between robotic and conventional open thyroid surgery for papillary thyroid microcarcinoma. Surgery. 2012;151(5):724–730.PubMedCrossRef Lee S, Ryu HR, Park JH, et al. Early surgical outcomes comparison between robotic and conventional open thyroid surgery for papillary thyroid microcarcinoma. Surgery. 2012;151(5):724–730.PubMedCrossRef
21.
Zurück zum Zitat Tae K, Ji YB, Cho SH, Lee SH, Kim DS, Kim TW. Early surgical outcomes of robotic thyroidectomy by a gasless unilateral axillo-breast or axillary approach for papillary thyroid carcinoma: 2 years’ experience. Head Neck. 2012;34(5):617–625.PubMedCrossRef Tae K, Ji YB, Cho SH, Lee SH, Kim DS, Kim TW. Early surgical outcomes of robotic thyroidectomy by a gasless unilateral axillo-breast or axillary approach for papillary thyroid carcinoma: 2 years’ experience. Head Neck. 2012;34(5):617–625.PubMedCrossRef
22.
Zurück zum Zitat Aliyev S, Taskin HE, Agcaoglu O, et al. Robotic transaxillary total thyroidectomy through a single axillary incision. Surgery. 2013;153(5):705–710.PubMedCrossRef Aliyev S, Taskin HE, Agcaoglu O, et al. Robotic transaxillary total thyroidectomy through a single axillary incision. Surgery. 2013;153(5):705–710.PubMedCrossRef
23.
Zurück zum Zitat Ryu HR, Lee J, Park JH, et al. A comparison of postoperative pain after conventional open thyroidectomy and transaxillary single-incision robotic thyroidectomy: a prospective study. Ann Surg Oncol. 2013;20(7):2279–2284.PubMedCrossRef Ryu HR, Lee J, Park JH, et al. A comparison of postoperative pain after conventional open thyroidectomy and transaxillary single-incision robotic thyroidectomy: a prospective study. Ann Surg Oncol. 2013;20(7):2279–2284.PubMedCrossRef
24.
Zurück zum Zitat Yi O, Yoon JH, Lee YM, et al. Technical and oncologic safety of robotic thyroid surgery. Ann Surg Oncol. 2013;20(6):1927–1933.PubMedCrossRef Yi O, Yoon JH, Lee YM, et al. Technical and oncologic safety of robotic thyroid surgery. Ann Surg Oncol. 2013;20(6):1927–1933.PubMedCrossRef
25.
Zurück zum Zitat Yoo JY, Chae YJ, Cho HB, Park KH, Kim JS, Lee SY. Comparison of the incidence of postoperative nausea and vomiting between women undergoing open or robot-assisted thyroidectomy. Surg Endosc. 2013;27(4):1321–1325.PubMedCrossRef Yoo JY, Chae YJ, Cho HB, Park KH, Kim JS, Lee SY. Comparison of the incidence of postoperative nausea and vomiting between women undergoing open or robot-assisted thyroidectomy. Surg Endosc. 2013;27(4):1321–1325.PubMedCrossRef
26.
Zurück zum Zitat Kim WW, Kim JS, Hur SM, et al. Is robotic surgery superior to endoscopic and open surgeries in thyroid cancer? World J Surg. 2011;35(4):779–784.PubMedCrossRef Kim WW, Kim JS, Hur SM, et al. Is robotic surgery superior to endoscopic and open surgeries in thyroid cancer? World J Surg. 2011;35(4):779–784.PubMedCrossRef
27.
Zurück zum Zitat Kang SW, Jeong JJ, Yun JS, et al. Robot-assisted endoscopic surgery for thyroid cancer: experience with the first 100 patients. Surg Endosc. 2009;23(11):2399–2406.PubMedCrossRef Kang SW, Jeong JJ, Yun JS, et al. Robot-assisted endoscopic surgery for thyroid cancer: experience with the first 100 patients. Surg Endosc. 2009;23(11):2399–2406.PubMedCrossRef
28.
Zurück zum Zitat Lee J, Kang SW, Jung JJ, et al. Multicenter study of robotic thyroidectomy: short-term postoperative outcomes and surgeon ergonomic considerations. Ann Surg Oncol. 2011;18(9):2538–2547.PubMedCrossRef Lee J, Kang SW, Jung JJ, et al. Multicenter study of robotic thyroidectomy: short-term postoperative outcomes and surgeon ergonomic considerations. Ann Surg Oncol. 2011;18(9):2538–2547.PubMedCrossRef
29.
Zurück zum Zitat Tae K, Ji YB, Jeong JH, Lee SH, Jeong MA, Park CW. Robotic thyroidectomy by a gasless unilateral axillo-breast or axillary approach: our early experiences. Surg Endosc. 2011;25(1):221–228.PubMedCrossRef Tae K, Ji YB, Jeong JH, Lee SH, Jeong MA, Park CW. Robotic thyroidectomy by a gasless unilateral axillo-breast or axillary approach: our early experiences. Surg Endosc. 2011;25(1):221–228.PubMedCrossRef
30.
Zurück zum Zitat Broome JT, Pomeroy S, Solorzano CC. Expense of robotic thyroidectomy: a cost analysis at a single institution. Arch Surg. 2012;147(12):1102–1106.PubMedCrossRef Broome JT, Pomeroy S, Solorzano CC. Expense of robotic thyroidectomy: a cost analysis at a single institution. Arch Surg. 2012;147(12):1102–1106.PubMedCrossRef
31.
Zurück zum Zitat Cabot JC, Lee CR, Brunaud L, et al. Robotic and endoscopic transaxillary thyroidectomies may be cost prohibitive when compared to standard cervical thyroidectomy: a cost analysis. Surgery. 2012;152(6):1016–1024.PubMedCrossRef Cabot JC, Lee CR, Brunaud L, et al. Robotic and endoscopic transaxillary thyroidectomies may be cost prohibitive when compared to standard cervical thyroidectomy: a cost analysis. Surgery. 2012;152(6):1016–1024.PubMedCrossRef
32.
Zurück zum Zitat Foley CS, Agcaoglu O, Siperstein AE, Berber E. Robotic transaxillary endocrine surgery: a comparison with conventional open technique. Surg Endosc. 2012;26(8):2259–2266.PubMedCrossRef Foley CS, Agcaoglu O, Siperstein AE, Berber E. Robotic transaxillary endocrine surgery: a comparison with conventional open technique. Surg Endosc. 2012;26(8):2259–2266.PubMedCrossRef
33.
Zurück zum Zitat Lee J, Na KY, Kim RM, et al. Postoperative functional voice changes after conventional open or robotic thyroidectomy: a prospective trial. Ann Surg Oncol. 2012;19(9):2963–2970.PubMedCrossRef Lee J, Na KY, Kim RM, et al. Postoperative functional voice changes after conventional open or robotic thyroidectomy: a prospective trial. Ann Surg Oncol. 2012;19(9):2963–2970.PubMedCrossRef
34.
Zurück zum Zitat Tae K, Kim KY, Yun BR, et al. Functional voice and swallowing outcomes after robotic thyroidectomy by a gasless unilateral axillo-breast approach: comparison with open thyroidectomy. Surg Endosc. 2012;26(7):1871–1877.PubMedCrossRef Tae K, Kim KY, Yun BR, et al. Functional voice and swallowing outcomes after robotic thyroidectomy by a gasless unilateral axillo-breast approach: comparison with open thyroidectomy. Surg Endosc. 2012;26(7):1871–1877.PubMedCrossRef
35.
Zurück zum Zitat Lee KE, Koo DH, Im HJ, et al. Surgical completeness of bilateral axillo-breast approach robotic thyroidectomy: comparison with conventional open thyroidectomy after propensity score matching. Surgery. 2011;150(6):1266–1274.PubMedCrossRef Lee KE, Koo DH, Im HJ, et al. Surgical completeness of bilateral axillo-breast approach robotic thyroidectomy: comparison with conventional open thyroidectomy after propensity score matching. Surgery. 2011;150(6):1266–1274.PubMedCrossRef
36.
Zurück zum Zitat Kim JA, Kim JS, Chang MS, Yoo YK, Kim DK. Influence of carbon dioxide insufflation of the neck on intraocular pressure during robot-assisted endoscopic thyroidectomy: a comparison with open thyroidectomy. Surg Endosc. 2013;27(5):1587–1593.PubMedCrossRef Kim JA, Kim JS, Chang MS, Yoo YK, Kim DK. Influence of carbon dioxide insufflation of the neck on intraocular pressure during robot-assisted endoscopic thyroidectomy: a comparison with open thyroidectomy. Surg Endosc. 2013;27(5):1587–1593.PubMedCrossRef
37.
Zurück zum Zitat Lee J, Lee JH, Nah KY, Soh EY, Chung WY. Comparison of endoscopic and robotic thyroidectomy. Ann Surg Oncol. 2011;18(5):1439–1446.PubMedCrossRef Lee J, Lee JH, Nah KY, Soh EY, Chung WY. Comparison of endoscopic and robotic thyroidectomy. Ann Surg Oncol. 2011;18(5):1439–1446.PubMedCrossRef
38.
Zurück zum Zitat Konia MR, Reiner M, Apostolido I. Acute persistent brachial plexopathy after robot-assisted transaxillary right thyroid lobe resection. J Clin Anesth. 2013;25(2):166–169.PubMedCrossRef Konia MR, Reiner M, Apostolido I. Acute persistent brachial plexopathy after robot-assisted transaxillary right thyroid lobe resection. J Clin Anesth. 2013;25(2):166–169.PubMedCrossRef
39.
Zurück zum Zitat Luginbuhl A, Schwartz DM, Sestokas AK, Cognetti D, Pribitkin E. Detection of evolving injury to the brachial plexus during transaxillary robotic thyroidectomy. Laryngoscope. 2012;122(1):110–115.PubMedCrossRef Luginbuhl A, Schwartz DM, Sestokas AK, Cognetti D, Pribitkin E. Detection of evolving injury to the brachial plexus during transaxillary robotic thyroidectomy. Laryngoscope. 2012;122(1):110–115.PubMedCrossRef
Metadaten
Titel
A Systematic Review and Meta-analysis Comparing Surgically-Related Complications between Robotic-Assisted Thyroidectomy and Conventional Open Thyroidectomy
verfasst von
Brian Hung-Hin Lang, MS, FRACS
Carlos K. H. Wong, PhD
Julian Shun Tsang, MBBS, MRCS
Kai Pun Wong, MBBS, FRCS
Koon Yat Wan, MBBS, FRCR
Publikationsdatum
01.03.2014
Verlag
Springer US
Erschienen in
Annals of Surgical Oncology / Ausgabe 3/2014
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-013-3406-7

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