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Annals of Surgical Oncology
Erschienen in: Annals of Surgical Oncology 2/2015

01.02.2015 | Pancreatic Tumors

Blood Neutrophil–Lymphocyte Ratio Predicts Survival in Patients with Advanced Pancreatic Cancer Treated with Chemotherapy

verfasst von: Guopei Luo, MD, PhD, Meng Guo, PhD, Zuqiang Liu, MD, Zhiwen Xiao, MD, Kaizhou Jin, MD, PhD, Jiang Long, MD, PhD, Liang Liu, MD, PhD, Chen Liu, MD, PhD, Jin Xu, MD, PhD, Quanxing Ni, MD, Xianjun Yu, MD, PhD

Erschienen in: Annals of Surgical Oncology | Ausgabe 2/2015

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Abstract

Background

Although a high neutrophil-to-lymphocyte ratio (NLR) has been reported to be a predictor of poor survival in patients with pancreatic cancers, its prognostic role in patients with advanced pancreatic cancer undergoing chemotherapy remains unclear. This study was performed to determine the prognostic role of NLR in patients with advanced pancreatic cancer undergoing chemotherapy.

Methods

We retrospectively enrolled 403 patients undergoing chemotherapy for advanced pancreatic adenocarcinoma from 2002 to 2013. Univariate and multivariate analyses were performed to identify clinicopathological predictors of overall survival including baseline NLR (NLR before chemotherapy) and postchemotherapy NLR change (NLR change before and after one cycle of chemotherapy), using the Cox proportional hazards model. Clinicopathological characteristics related to baseline NLR and postchemotherapy NLR change were evaluated.

Results

Univariate and multivariate analyses showed that both baseline NLR (NLR ≥ 3.1 vs. NLR < 3.1, hazard ratio [HR] = 1.42; P = 0.001) and postchemotherapy NLR change (NLR ≥ 3.1 and increased vs. NLR < 3.1 and decreased, HR = 2.39; P = 0.000) were independent prognostic factors in overall survival. NLR ≥ 3.1 before chemotherapy and NLR postchemotherapy change were significantly correlated with distant metastasis, serum CA19-9 levels, and serum albumin levels.

Conclusions

Baseline NLR and postchemotherapy NLR change may serve as potential biomarkers for overall survival in patients with advanced pancreatic cancer undergoing chemotherapy.
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Metadaten
Titel
Blood Neutrophil–Lymphocyte Ratio Predicts Survival in Patients with Advanced Pancreatic Cancer Treated with Chemotherapy
verfasst von
Guopei Luo, MD, PhD
Meng Guo, PhD
Zuqiang Liu, MD
Zhiwen Xiao, MD
Kaizhou Jin, MD, PhD
Jiang Long, MD, PhD
Liang Liu, MD, PhD
Chen Liu, MD, PhD
Jin Xu, MD, PhD
Quanxing Ni, MD
Xianjun Yu, MD, PhD
Publikationsdatum
01.02.2015
Verlag
Springer US
Erschienen in
Annals of Surgical Oncology / Ausgabe 2/2015
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-014-4021-y

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