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Erschienen in: Annals of Surgical Oncology 5/2018

05.02.2018 | Pancreatic Tumors

Significance of Glucose Transporter Type 1 (GLUT-1) Expression in the Therapeutic Strategy for Pancreatic Ductal Adenocarcinoma

verfasst von: Hiroshi Kurahara, MD, PhD, Kosei Maemura, MD, PhD, Yuko Mataki, MD, PhD, Masahiko Sakoda, MD, PhD, Satoshi Iino, MD, PhD, Yota Kawasaki, MD, PhD, Takaaki Arigami, MD, PhD, Shinichiro Mori, MD, PhD, Yuko Kijima, MD, PhD, Shinichi Ueno, MD, PhD, Hiroyuki Shinchi, MD, PhD, Shoji Natsugoe, MD, PhD

Erschienen in: Annals of Surgical Oncology | Ausgabe 5/2018

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Abstract

Background

This study aimed to examine the prognostic relevance of glucose transporter type 1 (GLUT-1), which is a key regulator of the glucose metabolism. In particular, the study aimed to examine the association between GLUT-1 expression and the therapeutic effect of chemoradiotherapy (CRT) in pancreatic ductal adenocarcinoma (PDAC).

Methods

Patients with PDAC were enrolled in the study. Patients with distant metastases and those who received only chemotherapy as treatment were excluded from the study. Specimens for immunohistochemical evaluations were obtained through surgical resection and endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of the primary tumor before any treatment.

Results

This study included 197 patients. Of these 197 patients, 100 underwent upfront surgery, and 97 received neoadjuvant CRT (NACRT), which was performed mainly for patients with locally advanced tumors. Of the 97 patients who received NACRT, 21 later underwent surgical resection. For the patients who underwent upfront surgery, low GLUT-1 expression was an independent factor for a better prognosis. For the patients who underwent NACRT, low GLUT-1 expression was significantly associated with greater tumor size reduction, a higher resection rate, and a better prognosis. Additionally, GLUT-1 expression was significantly increased after NACRT treatment.

Conclusions

Among the patients with PDAC, those with low GLUT-1 expression in the primary tumor had a better prognosis those with high GLUT-1 expression. Moreover, the patients with low GLUT-1 expression displayed a better therapeutic response to NACRT.
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Metadaten
Titel
Significance of Glucose Transporter Type 1 (GLUT-1) Expression in the Therapeutic Strategy for Pancreatic Ductal Adenocarcinoma
verfasst von
Hiroshi Kurahara, MD, PhD
Kosei Maemura, MD, PhD
Yuko Mataki, MD, PhD
Masahiko Sakoda, MD, PhD
Satoshi Iino, MD, PhD
Yota Kawasaki, MD, PhD
Takaaki Arigami, MD, PhD
Shinichiro Mori, MD, PhD
Yuko Kijima, MD, PhD
Shinichi Ueno, MD, PhD
Hiroyuki Shinchi, MD, PhD
Shoji Natsugoe, MD, PhD
Publikationsdatum
05.02.2018
Verlag
Springer International Publishing
Erschienen in
Annals of Surgical Oncology / Ausgabe 5/2018
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-6357-1

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