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Annals of Surgical Oncology
Erschienen in: Annals of Surgical Oncology 1/2019

02.11.2018 | Hepatobiliary Tumors

A Systematic Review and Meta-Analysis Comparing the Short- and Long-Term Outcomes for Laparoscopic and Open Liver Resections for Hepatocellular Carcinoma: Updated Results from the European Guidelines Meeting on Laparoscopic Liver Surgery, Southampton, UK, 2017

verfasst von: Ruben Ciria, MD, PhD, Irene Gomez-Luque, MD, Sira Ocaña, MD, Federica Cipriani, MD, PhD, Mark Halls, MBBS, Javier Briceño, MD, PhD, Yukihiro Okuda, MD, PhD, Roberto Troisi, MD, PhD, Fernando Rotellar, MD, PhD, Olivier Soubrane, MD, PhD, Mohammed Abu Hilal, MD, PhD

Erschienen in: Annals of Surgical Oncology | Ausgabe 1/2019

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Abstract

Background

The laparoscopic approach to liver resection has experienced exponential growth in recent years; however, its application is still under debate and objective, evidence-based guidelines for its safe future progression are needed.

Objective

The aim of this study was to perform a systematic review and meta-analysis comparing the short- and long-term outcomes of laparoscopic and open liver resections for hepatocellular carcinoma (HCC).

Methods

To identify all the comparative manuscripts reporting on laparoscopic and open liver resection for HCC, all published English-language studies with more than 10 cases were screened. In addition to the primary meta-analysis, four specific subgroup analyses were performed on patients with Child–Pugh A cirrhosis, resections for solitary tumors, and those undergoing minor and major resections. The quality of the studies was assessed using the Scottish Intercollegiate Guidelines Network (SIGN) methodology and the Newcastle–Ottawa Scale.

Results

From the initial 361 manuscripts, 28 were included in the meta-analysis. Five of these 28 manuscripts were specific to patients with Child–Pugh A cirrhosis (321 cases), 11 focused on solitary tumors (1003 cases), 16 focused on minor resections (1286 cases), and 3 focused on major resections (164 cases). Three manuscripts compared 1079 cases but could not be assigned to any of the above subanalyses. In general terms, short-term outcomes were favorable when using a laparoscopic approach, especially in minor resections. The only advantage seen with an open approach was reduced operative time during major liver resections. No differences in long-term outcomes were observed between the approaches.

Conclusions

Laparoscopic liver resection for HCC is feasible and offers improved short-term outcomes, with comparable long-term outcomes as the open approach.
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Metadaten
Titel
A Systematic Review and Meta-Analysis Comparing the Short- and Long-Term Outcomes for Laparoscopic and Open Liver Resections for Hepatocellular Carcinoma: Updated Results from the European Guidelines Meeting on Laparoscopic Liver Surgery, Southampton, UK, 2017
verfasst von
Ruben Ciria, MD, PhD
Irene Gomez-Luque, MD
Sira Ocaña, MD
Federica Cipriani, MD, PhD
Mark Halls, MBBS
Javier Briceño, MD, PhD
Yukihiro Okuda, MD, PhD
Roberto Troisi, MD, PhD
Fernando Rotellar, MD, PhD
Olivier Soubrane, MD, PhD
Mohammed Abu Hilal, MD, PhD
Publikationsdatum
02.11.2018
Verlag
Springer International Publishing
Erschienen in
Annals of Surgical Oncology / Ausgabe 1/2019
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-6926-3

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