Biotransformation of Physalin H and Leishmanicidal Activity of Its Transformed Products

Muhammad Iqbal Choudhary; Sammer Yousuf; Samreen; Syed Adnan Ali Shah; Shakil Ahmed; Atta-ur-Rahman

doi:10.1248/cpb.54.927

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Biotransformation of Physalin H and Leishmanicidal Activity of Its Transformed Products

Muhammad Iqbal Choudhary, Sammer Yousuf, Samreen, Syed Adnan Ali Shah, Shakil Ahmed, Atta-ur-Rahman

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Keywords: microbial transformation, physalin, Rhizopus stolonifer, Cunninghamella elegans, antileishmanial

JOURNAL FREE ACCESS

2006 Volume 54 Issue 7 Pages 927-930

DOI https://doi.org/10.1248/cpb.54.927

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Abstract

The transformation of physalin H (1) with Rhizopus stolonifer and Cunninghamella elegans has afforded two new physalins, 6,7-dehydrophysalin H (2) and 6-deoxyphysalin H (3), along with a known isophysalin B (4). Their structures were elucidated by spectroscopic analysis. All of these compounds have shown potent leishmanicidal activity with IC₅₀ values in the range of 6.03—13.80 μM.

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