We investigated the effects of human urinary kallidinogenase (SK-827) on cerebral metabolism in normal and infarcted rabbits. SK-827 did not influence cerebral glucose and oxygen uptake in normal rabbits. In infarcted rabbits, cerebral glucose and oxygen uptake significantly decreased. SK-827 tended to inhibit the decrease of cerebral blood flow, and significantly inhibited the decrease of cerebral glucose and oxygen uptake in infarcted rabbits. Thus, SK-827 improved cerebral glucose metabolism in infarcted rabbits.