Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Effects of (+)-Catechin on the Function of Osteoblastic Cells
Eun-Mi ChoiJae-Kwan Hwang
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2003 Volume 26 Issue 4 Pages 523-526

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Abstract

Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are candidate cytokines which are produced by osteoblastic linage cells and promote osteoblast apoptosis, osteoclastogenesis and bone resorption. Here, we examined the effect of (+)-catechin, one of the most common grape flavonols, on osteoblastic MC3T3-E1 cells. (+)-Catechin caused a significant elevation of cell survival at 10−5 and 10−4 M and alkaline phosphatase activity at 10−5 M. Also, treatment with (+)-catechin (10−5 M) decreased bone-resorbing cytokines (TNF-α and IL-6) production and apoptosis in osteoblasts. Our data indicate that the reduction of bone-resorbing cytokines and apoptosis in osteoblasts by (+)-catechin may result in the prevention and therapy for osteoporosis and inflammatory bone diseases.

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© 2003 The Pharmaceutical Society of Japan
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