Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Xanthine Oxidase Inhibitory Activities and Crystal Structures of Methoxyflavones from Kaempferia parviflora Rhizome
Kikuyo Nakao, Kazuya Murata, Takahiro Deguchi, Kimihisa Itoh, Takanori Fujita, Masayuki Higashino, Yuri Yoshioka, Shin-ichi Matsumura, Rika Tanaka, Tetsuro Shinada, Yasufumi Ohfune, Hideaki Matsuda
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Keywords: Zingiberaceae, Kaempferia parviflora, rhizome, xanthine oxidase, methoxyflavone, crystal structure
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2011 Volume 34 Issue 7 Pages 1143-1146

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Abstract

Kaempferia parviflora (KP), a Zingiberaceae plant, is used as a folk medicine in Thailand for the treatment of various symptoms, including general pains, colic gastrointestinal disorders, and male impotence. In this study, the inhibitory activities of KP against xanthine oxidase (XOD) were investigated. The extract of KP rhizomes showed more potent inhibitory activity (38% at 500 μg/ml) than those of the other Zingiberaceae plants tested. Ten methoxyflavones were isolated from the KP extract as the major chemical components and their chemical structures were elucidated by X-ray crystallography. The structurally confirmed methoxyflavones were subjected to the XOD inhibitory test. Among them, 3,5,7,4′,5′-pentamethoxyflavone and 3′,4′,5,7-tetramethoxyflavone showed inhibitory activities (IC50 of 0.9 and >4 mM, respectively) and their modes of inhibition are clarified as competitive/non-competitive mixed type. To the best of our knowledge, this is the first report to present the inhibitory activities of KP, 3,5,7,4′,5′-pentamethoxyflavone and 3′,4′,5,7-tetramethoxyflavone against XOD.

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© 2011 The Pharmaceutical Society of Japan
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