Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Excretion of Perfluorochemicals after Intravenous Injection of Their Emulsion
KAZUMASA YOKOYAMAKOUICHI YAMANOUCHIRYOICHIRO MURASHIMA
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1975 Volume 23 Issue 6 Pages 1368-1373

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Abstract

As a part of studies on perfluorochemicals for candidate as an artificial blood, the elimination of six kinds of the substance was studied to find the way and type of excretion in rats given their emulsions intravenously. (1) These compounds are solely excreted through expiration, none through urinary and biliary with an exception of FC-43 (perfluorotrifbutylamine. (2) The elimination curves of these compounds from the body appear to be exponential). (3) The elimination rate of each substance was fairly related to its vapor pressure, the higher, the more rapidly eliminated. (4) Within six compounds examined sofar, FDC (perfluorodecalin) is selected on account of its rapid elimination.

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© The Pharmaceutical Society of Japan
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