ISOLATION AND STRUCTURE OF REGELIN AND REGELINOL, NEW ANTITUMOR URSENE-TYPE TRITERPENOIDS FROM TRIPTERYGIUM REGELII

Hitoshi Hori; Guo-Mao Pang; Kenzo Harimaya; Yoichi Iitaka; Seiichi Inayama

doi:10.1248/cpb.35.2125

Hitoshi Hori, Guo-Mao Pang, Kenzo Harimaya, Yoichi Iitaka, Seiichi Inayama

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Keywords: regelin, regelinol, wilforlide A, Tripterygium regelii, ursene, triterpenoid, ¹H-NMR, ¹³C-NMR, X-ray diffraction, antitumor activity

JOURNAL FREE ACCESS

1987 Volume 35 Issue 5 Pages 2125-2128

DOI https://doi.org/10.1248/cpb.35.2125

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Abstract

Regelin (1a), a new antitumor ursene-type triterpenoid, the major principle, and another new ursene-type regelinol (1c) were isolated together with oleanene-type regelide (2) from the roots of Tripterygium regelii. The respective structures of la and lc were determined, by ¹H-and ¹³C-NMR spectrometric studies and X-ray analysis of 1a, to be the methyl ester of 3-oxo-22α-hydroxy-urs-12-en-30-oic acid and its 23-hydroxy analogue. 2 was found to be identical with wilforlide A or abruslactone A by comparing their physico-chemical data.

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