Biopharmaceutical Studies of Thiazide Diuretics. III. In Vivo Formation of 2-Amino-4-chloro-m-benzenedisulfonamide as a Metabolite of Hydrochlorothiazide in a Patient

TERUAKI OKUDA; SOICHI ITOH; MASARU YAMAZAKI; HAJIME NAKAHAMA; YOSHIFUMI FUKUHARA; YOSHIMASA ORITA

doi:10.1248/cpb.35.3516

Biopharmaceutical Studies of Thiazide Diuretics. III. In Vivo Formation of 2-Amino-4-chloro-m-benzenedisulfonamide as a Metabolite of Hydrochlorothiazide in a Patient

TERUAKI OKUDA, SOICHI ITOH, MASARU YAMAZAKI, HAJIME NAKAHAMA, YOSHIFUMI FUKUHARA, YOSHIMASA ORITA

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Keywords: hydrochlorothiazide, hydrolysate, 2-amino-4-chloro-m-benzenedisulfonamide, plasma, urine, erythrocyte, nephrotic patient, metabolite

JOURNAL FREE ACCESS

1987 Volume 35 Issue 8 Pages 3516-3518

DOI https://doi.org/10.1248/cpb.35.3516

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Abstract

Urine, plasma and erythrocytes from a patient receiving hydrochlorothiazide were examined by high-performance liquid chromatography. The urine and erythrocyte showed an unknown peak in the chromatograms. This substance was identified as 2-amino-4-chloro-m-benzenedisulfonamide and the identification was confirmed by comparison of the substance with an authentic sample obtained by synthesis. All data were analyzed with a PC 9801VM computer in conjunction with a JASCO MULTI-320 multi-wavelength ultraviolet detector.

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