Two new coumarins, paniculin (II) and coumurrin (V), were isolated from the leaves of Murraya paniculata (L.) JACK (Rutaceae), and their structures were elucidated on the basis of spectroscopic data. Another coumarin, named murpaniculol (III), was isolated for the first time as a natural product. Twelve other coumarins and two flavones of chemotaxonomical significance were also identified.