Coclauril (1), a nonglucosidic 2-cyclohexen-1-ylideneacetonitrile, was isolated from the leaves of Cocculus lauriforius DC. (Menispermaceae) collected at Ishigaki Island (Okinawa, Japan), and the structure was elucidated by spectroscopic means. Two known bicyclic butenolides, menisdaurilide (8) adn aquilegiolide (9), were also characterized.