Amino Acids and Peptides. XVII. Synthesis of Peptides Related to N-Terminal Portion of Fibrin α-Chain and Their Inhibitory Effect on Fibrinogen : Thrombin Clotting

Koichi KAWASAKI; Toshiki TSUJI; Katuhiko HIRASE; Masanori MIYANO; Sachiye INOUE; Masahiro IWAMOTO

doi:10.1248/cpb.41.525

Koichi KAWASAKI, Toshiki TSUJI, Katuhiko HIRASE, Masanori MIYANO, Sachiye INOUE, Masahiro IWAMOTO

Author information

Keywords: fibrin-α N-terminal, anticoagulant, peptide synthesis, acid hydrolysis, nitroarginine, fibrinogen/thrombin clotting

JOURNAL FREE ACCESS

1993 Volume 41 Issue 3 Pages 525-528

DOI https://doi.org/10.1248/cpb.41.525

Details

Abstract

Various peptides related to N-terminal portion of fibrin α-chain were synthesized by the solution method and the solid-phase method, and their inhibitory effect on fibrinogen/thrombin clotting was examined. Extension of peptide chain from N-terminal tripeptid decreased the inhibitory effect. The most potent effect was shown by N-terminal decapeptide analog, H-Gly-Pro-Arg-Pro-Pro-Glu-Arg-His-Gln-Ser-NH₂.

Corresponding author

Register with J-STAGE for free!