Isolation of Some Immunosuppressive Components from an Ascomycete, Gelasinospora multiforis

Haruhiro FUJIMOTO; Yuji SATOH; Megumi NAKAYAMA; Tomoe TAKAYAMA; Mikio YAMAZAKI

doi:10.1248/cpb.43.547

Haruhiro FUJIMOTO, Yuji SATOH, Megumi NAKAYAMA, Tomoe TAKAYAMA, Mikio YAMAZAKI

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Keywords: fungal metabolite, Ascomycete, Gelasinospora multiforis, immunosuppressant, multiforisin, α-pyrone(2H-pyran-2-one)

JOURNAL FREE ACCESS

1995 Volume 43 Issue 4 Pages 547-552

DOI https://doi.org/10.1248/cpb.43.547

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Abstract

Five new components, named multiforisins A, B, C, D, and E, with immunosuppressive activity were isolated from an Ascomycete, Gelasinospora multiforis. Multiforisin A, the main immunosuppressive principle of this fungus, was deduced to be 5-formyl-3-(hydroxymethyl)-4-methoxy-6-(1E-propenyl)-α-pyrone. Multiforisins B, C, D, and E were also deduced to be α-pyrone derivatives related to multiforisin A. The IC₅₀ values of multiforisins A, B, C, D, E, and dihydro multiforisin A were evaluated against proliferation of mouse spleen lymphocytes stimulated with concanavalin A and lipopolysaccharide.

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