Synthesis and Antitumor Activity of Fused Quinoline Derivatives. IV. Novel 11-Aminoindolo[3, 2-b]quinolines

Yasuo TAKEUCHI; Toshiaki ODA; Ming-rong CHANG; Yoko OKAMOTO; Junko ONO; Yoko ODA; Kyoko HARADA; Kuniko HASHIGAKI; Masatoshi YAMATO

doi:10.1248/cpb.45.406

Yasuo TAKEUCHI, Toshiaki ODA, Ming-rong CHANG, Yoko OKAMOTO, Junko ONO, Yoko ODA, Kyoko HARADA, Kuniko HASHIGAKI, Masatoshi YAMATO

Author information

Yasuo TAKEUCHI
Toshiaki ODA
Ming-rong CHANG
Yoko OKAMOTO
Junko ONO
Yoko ODA
Kyoko HARADA
Kuniko HASHIGAKI
Masatoshi YAMATO
Author's Organization：
Faculty of Pharmaceutical Sciences, Okayama University
Faculty of Pharmaceutical Sciences, Okayama University
Faculty of Pharmaceutical Sciences, Okayama University
Faculty of Pharmaceutical Sciences, Okayama University
Faculty of Pharmaceutical Sciences, Okayama University
Faculty of Pharmaceutical Sciences, Okayama University
Faculty of Pharmaceutical Sciences, Okayama University
Faculty of Pharmaceutical Sciences, Okayama University
Department of Science, Okayama University of Science

Keywords: indolo[3, 2-b]quinoline, synthesis, antitumor activity, structure-activity relationship, quinone diimine

JOURNAL FREE ACCESS

1997 Volume 45 Issue 2 Pages 406-411

DOI https://doi.org/10.1248/cpb.45.406

Details

Abstract

Indolo[3, 2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.

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