First Natural Urease Inhibitor from Euphorbia decipiens

Viqar Uddin Ahmad; Javid Hussain; Hidayat Hussain; Amir Reza Jassbi; Farman Ullah; Muhammad Arif Lodhi; Amsha Yasin; Muhammad Iqbal Choudhary

doi:10.1248/cpb.51.719

Notes

First Natural Urease Inhibitor from Euphorbia decipiens

Viqar Uddin Ahmad, Javid Hussain, Hidayat Hussain, Amir Reza Jassbi, Farman Ullah, Muhammad Arif Lodhi, Amsha Yasin, Muhammad Iqbal Choudhary

Author information

Viqar Uddin Ahmad
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi
Javid Hussain
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi
Hidayat Hussain
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi
Amir Reza Jassbi
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi
Farman Ullah
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi
Muhammad Arif Lodhi
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi
Amsha Yasin
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi
Muhammad Iqbal Choudhary
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi

Keywords: Euphorbia decipiens, Euphorbiaceae, diterpene ester, myrsinol-type diterpene, urease, prolyl endopeptidase

JOURNAL FREE ACCESS

2003 Volume 51 Issue 6 Pages 719-723

DOI https://doi.org/10.1248/cpb.51.719

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Abstract

Three new diterpene esters with a myrsinol-type skeleton have been isolated from Euphorbia decipiens BOISS. & BUHSE. The structure elucidation of the isolated compounds was based primarily on two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC) and nuclear Overhauser effect spectroscopy (NOESY) experiments. Compounds 1 and 3 are active against prolyl endopeptidase and compound 2 showed inhibitory activity against urease enzyme.

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