Six Immunosuppressive Features from an Ascomycete, Zopfiella longicaudata, Found in a Screening Study Monitored by Immunomodulatory Activity

Haruhiro Fujimoto; Etsuko Nakamura; Emi Okuyama; Masami Ishibashi

doi:10.1248/cpb.52.1005

Notes

Six Immunosuppressive Features from an Ascomycete, Zopfiella longicaudata, Found in a Screening Study Monitored by Immunomodulatory Activity

Haruhiro Fujimoto, Etsuko Nakamura, Emi Okuyama, Masami Ishibashi

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Keywords: immunosuppressive fungal metabolite, Zopfiella longicaudata, Ascomycete, anthraquinone, ergostane, structure–activity relationship

JOURNAL FREE ACCESS

2004 Volume 52 Issue 8 Pages 1005-1008

DOI https://doi.org/10.1248/cpb.52.1005

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Abstract

In a screening study on immunomodulatory fungal metabolites, three known anthraquinones, carviolin (roseo-purpurin) (1), 1-O-methylemodin (2), ω-hydroxyemodin (citreorosein) (4), and a new anthraquinone, ω-acetylcarviolin (3), together with a known steroid, ergosta-4,6,8(14),22-tetraen-3-one (5) and a new steroid, 25-hydroxyergosta-4,6,8(14),22-tetraen-3-one (6) were isolated from an Ascomycete, Zopfiella longicaudata, and found to have moderate immunosuppressive activities. The structure–activity relationships of these metabolites are discussed.

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