New Cholinesterase Inhibiting Bisbenzylisoquinoline Alkaloids from Cocculus pendulus

Atta-Ur-Rahman; Atia-Tul-Wahab; Sarfraz Ahmad Nawaz; M. Iqbal Choudhary

doi:10.1248/cpb.52.802

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New Cholinesterase Inhibiting Bisbenzylisoquinoline Alkaloids from Cocculus pendulus

Atta-Ur-Rahman, Atia-Tul-Wahab, Sarfraz Ahmad Nawaz, M. Iqbal Choudhary

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Keywords: Cocculus pendulus, Menispermaceae, bisbenzylisoquinoline alkaloid, acetylcholinesterase, butyrylcholinesterase

JOURNAL FREE ACCESS

2004 Volume 52 Issue 7 Pages 802-806

DOI https://doi.org/10.1248/cpb.52.802

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Abstract

Phytochemical investigation on Cocculus pendulus (J. R. & G. FORST.) resulted in the isolation of two new and three known bisbenzylisoquinoline alkaloids. The structures of the new alkaloids, kurramine-2′-β-N-oxide (1) and kurramine-2′-α-N-oxide (2), were elucidated with the help of spectroscopic techniques. The cholinesterase inhibitory activities of these bisbenzylisoquinoline alkaloids are reported here for the first time.

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