Eleven New 2-Pyrones from a Fungi Imperfecti, Trichurus terrophilus, Found in a Screening Study Guided by Immunomodulatory Activity

Haruhiro Fujimoto; Yoshie Okamoto; Eriko Sone; Satomi Maeda; Kohki Akiyama; Masami Ishibashi

doi:10.1248/cpb.53.923

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Eleven New 2-Pyrones from a Fungi Imperfecti, Trichurus terrophilus, Found in a Screening Study Guided by Immunomodulatory Activity

Haruhiro Fujimoto, Yoshie Okamoto, Eriko Sone, Satomi Maeda, Kohki Akiyama, Masami Ishibashi

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Keywords: immunosuppressive fungal constituent, Trichurus terrophilus, Fungi Imperfecti, 2-pyrone, trichurusin, structure–activity relationship

JOURNAL FREE ACCESS

2005 Volume 53 Issue 8 Pages 923-929

DOI https://doi.org/10.1248/cpb.53.923

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Abstract

In a screening study on immunomodulatory fungal constituents, eleven new 2-pyrones tentatively named TT-1 (1), and TT-2—11 (2—11) have been isolated from a Fungi Imperfecti, Trichurus terrophilus, and designated rasfonin (1), and trichurusin B—K (2—11), respectively. Compounds 1—4 exhibited considerably high immunosuppressive activities, and compounds 8—11 have shown moderate ones. The structure–activity relationships of these constituents have also been discussed.

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