Major Metabolites of Zolpidem: Expeditious Synthesis and Mass Spectra

Frédérique Klupsch; Raymond Houssin; Luc Humbert; Michel Imbenotte; Jean-Pierre Hénichart; Michel Lhermitte

doi:10.1248/cpb.54.1318

Notes

Major Metabolites of Zolpidem: Expeditious Synthesis and Mass Spectra

Frédérique Klupsch, Raymond Houssin, Luc Humbert, Michel Imbenotte, Jean-Pierre Hénichart, Michel Lhermitte

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Keywords: Zolpidem, metabolite, regioselective cyclization, drug-facilitated crime, mass spectra

JOURNAL FREE ACCESS

2006 Volume 54 Issue 9 Pages 1318-1321

DOI https://doi.org/10.1248/cpb.54.1318

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Abstract

An expeditious route to the two major metabolites of Zolpidem—and readily applicable to the synthesis of the drug—was established via a cyclization reaction between a 2-aminopyridine and a suitable α-bromoacetophenone. The structures of the target compounds were confirmed from a 2D ¹H–¹⁵N NMR correlation. Their mass spectra contribute to a reliable toxicological identification of the drug in the case of drug-facilitated crimes.

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