Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Antiproliferative Constituents from Umbelliferae Plants. IX. New Triterpenoid Glycosides from the Fruits of Bupleurum rotundifolium
Toshihiro Fujioka, Keisuke Yoshida, Hiroko Shibao, Tsuneatsu Nagao, Miyako Yoshida, Kazuhisa Matsunaga, Jiro Takata, Yoshiharu Karube, Yukiko Iwase, Hikaru Okabe, Kunihide Mihashi
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Keywords: antiproliferative constituent, Bupleurum rotundifolium, Umbelliferae 13β,28-epoxy oleanane-type triterpene glycoside
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2006 Volume 54 Issue 12 Pages 1694-1704

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Abstract

The MeOH extract of the fruits of Bupleurum rotundifolium showed inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. Bioactivity-guided fractionation of the MeOH extract led to the isolation of four new triglycosides of 13β,28-epoxy oleanane-type triterpenes, named rotundiosides O, Q, S and T; 12 new glycosides of oleanane-type triterpenes, named rotundiosides J—N, P, R, U—Y, and others; echinocystic acid 3-O-sulfate; and three known oleanane-type triterpene glycosides, rotundiosides A, F and G. The structures of the new isolates were determined based on chemical and spectroscopic evidence. The GI50 of isolates against MK-1, HeLa and B16F10 cell lines are reported.

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© 2006 The Pharmaceutical Society of Japan
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