Naturally occurring new iridoids and secoiridoids published during 2005—2008 are reviewed with available physical and spectral data: mp, [α]_D, UV, IR, ¹H- and ¹³C-NMR and plant source. The works on biological and pharmacological activity of naturally occurring iridoids and secoiridoids reported during 2005—2008 are also reviewed. Bioactivities like antibacterial, anticancer, anticoagulant, antifungal, anti-inflammatory, antioxidative, antiprotozoal, hepatoprotective and neuroprotective activities are highlighted.