Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Regular Articles
Garlicnin A from the Fraction Regulating Macrophage Activation of Allium sativum
Mona El-Aasr, Yukio Fujiwara, Motohiro Takeya, Masateru Ono, Daisuke Nakano, Masafumi Okawa, Junei Kinjo, Tsuyoshi Ikeda, Hiroyuki Miyashita, Hitoshi Yoshimitsu, Toshihiro Nohara
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Keywords: Allium sativum, sulfoxide, garlicnin A, macrophage activation
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2011 Volume 59 Issue 11 Pages 1340-1343

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Abstract

Garlicnin A (1), a new stable, sulfur-containing compound isolated from a fraction of the acetone extracts of Allium sativum L. garlic bulbs, showed the potential to suppress tumor cell proliferation by inhibiting the polarization of M2 alternatively activated macrophages, and its structure was characterized as 3,4-dimethyl-5-(4,5-dithia-1E,7-octadiene)-tetrahydrothiophene-2-sulfoxide-S-oxide, on the basis of the results of spectroscopic analysis results.

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© 2011 The Pharmaceutical Society of Japan
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