Structures of Two New Phenolic Glycosides, Kaempferiaosides A and B, and Hepatoprotective Constituents from the Rhizomes of Kaempferia parviflora

Saowanee Chaipech; Toshio Morikawa; Kiyofumi Ninomiya; Masayuki Yoshikawa; Yutana Pongpiriyadacha; Takao Hayakawa; Osamu Muraoka

doi:10.1248/cpb.60.62

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Structures of Two New Phenolic Glycosides, Kaempferiaosides A and B, and Hepatoprotective Constituents from the Rhizomes of Kaempferia parviflora

Saowanee Chaipech, Toshio Morikawa, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka

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Keywords: Kaempferia parviflora, Zingiberaceae, kaempferiaoside, hepatoprotective activity, Krachai Dum

JOURNAL FREE ACCESS

2012 Volume 60 Issue 1 Pages 62-69

DOI https://doi.org/10.1248/cpb.60.62

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Abstract

Two new phenolic glycosides, kaempferiaosides A and B were isolated from the rhizomes of Kaempferia parviflora (Zingiberaceae) together with 24 known compounds. Their structures including absolute stereochemistry were elucidated on the basis of chemical and spectroscopic evidence. Among the isolates, 5,3′-dihydroxy-3,7,4′-trimethoxyflavone showed higher activity than silybin, a commercial hepatoprotective agent.

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