Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Chemical Structures and Hepatoprotective Effects of Constituents from Cassia auriculata Leaves
Seikou Nakamura, Fengming Xu, Kiyofumi Ninomiya, Souichi Nakashima, Yoshimi Oda, Toshio Morikawa, Osamu Muraoka, Masayuki Yoshikawa, Hisashi Matsuda
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Keywords: Cassia auriculata, avaraoside I, avaraol I, Ayurvedic traditional medicine, hepatoprotective effect
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2014 Volume 62 Issue 10 Pages 1026-1031

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Abstract

An 80% aqueous acetone extract of Cassia auriculata leaves was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. From the 80% aqueous acetone extract, we isolated a new benzocoumarin glycoside, avaraoside I (1), and a new flavanol dimer, avaraol I (2), together with 29 known constituents. The structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. In addition, three isolated compounds, pseudosemiglabrin (15, 0.0011%), (2S)-7,4′-dihydroxyflavan(4β→8)-catechin (22, 0.00075%), and (2S)-7,4′-dihydroxyflavan(4β→8)-gallocatechin (23, 0.092%), displayed hepatoprotective effects equivalent to that of the hepatoprotective agent, silybin.

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© 2014 The Pharmaceutical Society of Japan
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