Administration of Atrial Natriuretic Peptide Attenuates Reperfusion Phenomena and Preserves Left Ventricular Regional Wall Motion After Direct Coronary Angioplasty for Acute Myocardial Infarction

Hideyo Kuga; Kenichi Ogawa; Akitugu Oida; Isao Taguchi; Masatoshi Nakatsugawa; Toshiyasu Hoshi; Hiroyasu Sugimura; Shichirou Abe; Noboru Kaneko

doi:10.1253/circj.67.443

Clinical Investigation

Administration of Atrial Natriuretic Peptide Attenuates Reperfusion Phenomena and Preserves Left Ventricular Regional Wall Motion After Direct Coronary Angioplasty for Acute Myocardial Infarction

Hideyo Kuga, Kenichi Ogawa, Akitugu Oida, Isao Taguchi, Masatoshi Nakatsugawa, Toshiyasu Hoshi, Hiroyasu Sugimura, Shichirou Abe, Noboru Kaneko

Author information

Hideyo Kuga
Department of Cardiology and Pneumology, Dokkyo University School of Medicine
Kenichi Ogawa
Department of Cardiology and Pneumology, Dokkyo University School of Medicine
Akitugu Oida
Department of Cardiology and Pneumology, Dokkyo University School of Medicine
Isao Taguchi
Department of Cardiology and Pneumology, Dokkyo University School of Medicine
Masatoshi Nakatsugawa
Department of Cardiology and Pneumology, Dokkyo University School of Medicine
Toshiyasu Hoshi
Department of Cardiology and Pneumology, Dokkyo University School of Medicine
Hiroyasu Sugimura
Department of Cardiology and Pneumology, Dokkyo University School of Medicine
Shichirou Abe
Department of Cardiology and Pneumology, Dokkyo University School of Medicine
Noboru Kaneko
Department of Cardiology and Pneumology, Dokkyo University School of Medicine

Keywords: Intracoronary administration, Left ventricular ejection fraction, Left ventricular end-diastolic volume index, Persistent ST-segment elevation, Ventricular tachycardia

JOURNAL FREE ACCESS

2003 Volume 67 Issue 5 Pages 443-448

DOI https://doi.org/10.1253/circj.67.443

Details

Abstract

To evaluate the effects of synthetic human atrial natriuretic peptide (hANP) on myocardial reperfusion injury and left ventricular remodeling, 19 patients within 12 h of a first attack of anterior myocardial infarction (AMI) underwent intracoronary injection of 25 μg of hANP immediately after coronary angioplasty, combined with intravenous infusion of 0.025 μg · kg^-1 · min^-1 of hANP initiated on admission for 1 week (hANP group); 18 similar patients had saline administered (control group). The incidences of premature ventricular contraction, ventricular tachycardia and/or fibrillation in the hANP group were significantly less than in the control group after coronary angioplasty. Left ventricular ejection fraction was significantly greater and left ventricular end-diastolic volume index was significantly smaller 6 months after coronary angioplasty. Left ventricular regional wall motion of the infarcted segments significantly increased. Thus, hANP remarkably suppressed reperfusion phenomena and preserved left ventricular function through improvement of regional wall motion of the infarcted segments after coronary angioplasty. (Circ J 2003; 67: 443 - 448)

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