Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Clinical Investigation
Investigation of the Optimal Treatment Strategy for Atrial Fibrillation in Japan
The J-RHYTHM (Japanese Rhythm Management Trial for Atrial Fibrillation) Study Design
Takeshi Yamashita, Satoshi Ogawa, Yoshifusa Aizawa, Hirotsugu Atarashi, Hiroshi Inoue, Tohru Ohe, Ken Okumura, Takao Kato, Shiro Kamakura, Koichiro Kumagai, Yoshihisa Kurachi, Itsuo Kodama, Yukihiro Koretsune, Tetsunori Saikawa, Masayuki Sakurai, Kaoru Sugi, Haruaki Nakaya, Toshio Nakayama, Makoto Hirai, Masahiko Fukatani, Hideo Mitamura, Tsutomu Yamazaki
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Keywords: Antiarrhythmic drugs, Atrial fibrillation, Quality of life
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2003 Volume 67 Issue 9 Pages 738-741

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Abstract

The Japanese Rhythm Management Trial for Atrial Fibrillation (J-RHYTHM study) is a randomized comparative evaluation of rate control and rhythm control, both combined with antithrombotic therapy, as therapeutic strategies for the treatment of atrial fibrillation (AF). This study differs from the earlier AFFIRM and RACE studies in that it has a composite primary end-point representing mortality and also physical/psychological disablement (total mortality, symptomatic cerebral infarction, systemic embolism, major bleeding, hospitalization for heart failure requiring intravenous administration of diuretics, and patient disablement). Patients' will to change the therapeutic strategy to the other is also considered as an end-point representing disablement under the assigned strategy. The secondary end-point includes quality of life scores and the efficacy and safety of drugs used in treating AF. The J-RHYTHM study emphasizes patient-reported experience and perception of AF-specific disablement, and the safety of antiarrhythmics available in Japan; it will follow 2,600 patients treated at more than 150 sites in Japan for a 3-year period. (Circ J 2003; 67: 738 - 741)

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© 2003 THE JAPANESE CIRCULATION SOCIETY
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