Effect of Combined Therapy of Danaparoid Sodium and Tranexamic Acid on Chronic Disseminated Intravascular Coagulation Associated With Abdominal Aortic Aneurysm

Yasuo Ontachi; Hidesaku Asakura; Masahisa Arahata; Yasuko Kadohira; Mio Maekawa; Tomoe Hayashi; Masahide Yamazaki; Eriko Morishita; Masanori Saito; Shinji Minami; Shinji Nakao

doi:10.1253/circj.69.1150

Case Report

Effect of Combined Therapy of Danaparoid Sodium and Tranexamic Acid on Chronic Disseminated Intravascular Coagulation Associated With Abdominal Aortic Aneurysm

Yasuo Ontachi, Hidesaku Asakura, Masahisa Arahata, Yasuko Kadohira, Mio Maekawa, Tomoe Hayashi, Masahide Yamazaki, Eriko Morishita, Masanori Saito, Shinji Minami, Shinji Nakao

Author information

Yasuo Ontachi
Department of Internal Medicine (III), Kanazawa University School of Medicine
Hidesaku Asakura
Department of Internal Medicine (III), Kanazawa University School of Medicine
Masahisa Arahata
Department of Internal Medicine (III), Kanazawa University School of Medicine
Yasuko Kadohira
Department of Internal Medicine (III), Kanazawa University School of Medicine
Mio Maekawa
Department of Internal Medicine (III), Kanazawa University School of Medicine
Tomoe Hayashi
Department of Internal Medicine (III), Kanazawa University School of Medicine
Masahide Yamazaki
Department of Internal Medicine (III), Kanazawa University School of Medicine
Eriko Morishita
Department of Internal Medicine (III), Kanazawa University School of Medicine
Masanori Saito
Department of Internal Medicine (III), Kanazawa University School of Medicine
Shinji Minami
Internal Medicine, Inami Hospital
Shinji Nakao
Department of Internal Medicine (III), Kanazawa University School of Medicine

Keywords: Abdominal aortic aneurysm (AAA), Danaparoid, Disseminated intravascular coagulation (DIC)

JOURNAL FREE ACCESS

2005 Volume 69 Issue 9 Pages 1150-1153

DOI https://doi.org/10.1253/circj.69.1150

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Abstract

Chronic disseminated intravascular coagulation (DIC) is a well-known complication of aortic aneurysm. A 63-year-old man with bleeding tendency and a large palpable abdominal aortic aneurysm (AAA) was diagnosed as having fibrinolysis dominant DIC by the excessive activation of both coagulation and fibrinolysis (plasmin -_α ₂ plasmin inhibitor complex concentration is usually >4 symbol>mg/ml). Although several treatments were tried, DIC could not be controlled until the patient was given combined therapy of danaparoid (1,250 U/12 h, bolus IV) and tranexamic acid (0.5 g × 3/day, oral administration). This therapy may be beneficial when control for bleeding is required without restricting the ambulatory movement of patients by continuous drip. (Circ J 2005; 69: 1150 - 1153)

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