Rationale and Design for a Study Using Intravascular Ultrasound to Evaluate Effects of Rosuvastatin on Coronary Artery Atheroma in Japanese Subjects COSMOS Study (Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects)

Tadateru Takayama; Takafumi Hiro; Masakazu Yamagishi; Hiroyuki Daida; Satoshi Saito; Tetsu Yamaguchi; Masunori Matsuzaki

doi:10.1253/circj.71.271

Clinical Investigation

Rationale and Design for a Study Using Intravascular Ultrasound to Evaluate Effects of Rosuvastatin on Coronary Artery Atheroma in Japanese Subjects

COSMOS Study (Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects)

Tadateru Takayama, Takafumi Hiro, Masakazu Yamagishi, Hiroyuki Daida, Satoshi Saito, Tetsu Yamaguchi, Masunori Matsuzaki

Author information

Keywords: Atherosclerosis, Coronary disease, Intravascular ultrasound, Lipids, Rosuvastatin

JOURNAL FREE ACCESS

2007 Volume 71 Issue 2 Pages 271-275

DOI https://doi.org/10.1253/circj.71.271

Details

Abstract

Background There have been few multicenter studies using intravascular ultrasound (IVUS) to assess the process of atherosclerosis in a Japanese population with hypercholesterolemia that is being treated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors for control of low-density lipoprotein-cholesterol. Methods and Results An open-label multicenter study is planned to evaluate with IVUS whether treatment with rosuvastatin for 76 weeks results in regression of coronary artery atheroma volume in patients who have coronary heart disease (CHD) and hypercholesterolemia. Sample size is 200 subjects with CHD who are to undergo percutaneous coronary intervention. The planned duration is between October 2005 and October 2008. Conclusions The COSMOS study will be the first multicenter cardiovascular study in a Japanese population and may provide new evidence on the effects of rosuvastatin on the progression of coronary atherosclerotic lesions. (Circ J 2007; 71: 271 -275)

Corresponding author

Register with J-STAGE for free!