Endothelial Lipase Gene Polymorphism is Associated With Acute Myocardial Infarction, Independently of High-Density Lipoprotein-Cholesterol Levels

Masakatsu Shimizu; Kenji Kanazawa; Ken-ichi Hirata; Tatsuro Ishida; Eiji Hiraoka; Yasuaki Matsuda; Chikao Iwai; Yoshitomo Miyamoto; Masayoshi Hashimoto; Teishi Kajiya; Hozuka Akita; Mitsuhiro Yokoyama

doi:10.1253/circj.71.842

Clinical Investigation

Endothelial Lipase Gene Polymorphism is Associated With Acute Myocardial Infarction, Independently of High-Density Lipoprotein-Cholesterol Levels

Masakatsu Shimizu, Kenji Kanazawa, Ken-ichi Hirata, Tatsuro Ishida, Eiji Hiraoka, Yasuaki Matsuda, Chikao Iwai, Yoshitomo Miyamoto, Masayoshi Hashimoto, Teishi Kajiya, Hozuka Akita, Mitsuhiro Yokoyama

Author information

Masakatsu Shimizu
Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine
Kenji Kanazawa
Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine
Ken-ichi Hirata
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Tatsuro Ishida
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Eiji Hiraoka
Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine
Yasuaki Matsuda
Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine
Chikao Iwai
Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine
Yoshitomo Miyamoto
Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine
Masayoshi Hashimoto
Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine
Teishi Kajiya
Department of Cardiology, Himeji Cardiovascular Center
Hozuka Akita
Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine
Mitsuhiro Yokoyama
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

Keywords: Acute myocardial infarction, Endothelial lipase, High-density lipoprotein-cholesterol, Single nucleotide polymorphism, Smoking

JOURNAL FREE ACCESS

2007 Volume 71 Issue 6 Pages 842-846

DOI https://doi.org/10.1253/circj.71.842

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Abstract

Background Endothelial lipase (EL) is a major determinant of high-density lipoprotein-cholesterol (HDL-C) metabolism and promotes monocytes recruitment. The local expression of EL could influence atherogenesis directly, in addition to its systemic role in HDL metabolism. The EL gene has a common 584C/T polymorphism, but it is unclear whether this polymorphism is associated with HDL-C levels or acute myocardial infarction (AMI). Methods and Results A case - control study of 107 AMI patients and 107 control subjects was conducted. T allele frequency was lower in the AMI group than in controls (0.18 vs 0.26, p<0.05). No significant association was found between the 584C/T polymorphism and HDL-C levels. Multivariate regression analyses showed that the association of the T allele with AMI was statistically significant and independent of other risk factors when age, sex, hypertension, hypercholesterolemia, and diabetes mellitus were included in the analyses (odds ratio (OR), 0.52; 95% confidence interval (95% CI) 0.28-0.98; p=0.04). However, when smoking status was included, the association of the T allele with AMI did not remain statistically significant (OR, 0.61; 95% CI 0.32-1.18; p=0.14). Conclusions The 584C/T polymorphism of the EL gene was associated with AMI independently of HDL-C levels and thus may be involved in the pathogenesis of AMI. (Circ J 2007; 71: 842 - 846)

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