High Ratio of Myeloid Dendritic Cells to Plasmacytoid Dendritic Cells in Blood of Patients With Acute Coronary Syndrome

Takashi Fukunaga; Hirofumi Soejima; Atsushi Irie; Ryuichiro Fukushima; Yoko Oe; Hiroaki Kawano; Hitoshi Sumida; Koichi Kaikita; Seigo Sugiyama; Yasuharu Nishimura; Hisao Ogawa

doi:10.1253/circj.CJ-08-1193

Ischemic Heart Disease

High Ratio of Myeloid Dendritic Cells to Plasmacytoid Dendritic Cells in Blood of Patients With Acute Coronary Syndrome

Takashi Fukunaga, Hirofumi Soejima, Atsushi Irie, Ryuichiro Fukushima, Yoko Oe, Hiroaki Kawano, Hitoshi Sumida, Koichi Kaikita, Seigo Sugiyama, Yasuharu Nishimura, Hisao Ogawa

Author information

Takashi Fukunaga
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Hirofumi Soejima
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Atsushi Irie
Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University
Ryuichiro Fukushima
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Yoko Oe
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Hiroaki Kawano
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Hitoshi Sumida
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Koichi Kaikita
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Seigo Sugiyama
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Yasuharu Nishimura
Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University
Hisao Ogawa
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

Keywords: Acute coronary syndrome, Interferon-α, Interleukin-12, Myeloid dendritic cells, Plasmacytoid dendritic cells

JOURNAL FREE ACCESS

2009 Volume 73 Issue 10 Pages 1914-1919

DOI https://doi.org/10.1253/circj.CJ-08-1193

View "Advance Publication" version (July 31, 2009).

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Abstract

Background: Dendritic cells (DCs) stimulate T-cells to participate in the inflammatory processes that promote the destruction of vulnerable plaques. The relationship between circulating levels of myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) in patients with acute coronary syndrome (ACS) was evaluated. Methods and Results: Blood samples were obtained from 39 patients with ACS, 41 patients with stable angina pectoris (SAP) and 43 controls. The proportion of mDCs tended to be lower in the ACS group than in the SAP group and controls. Interleukin-12 levels associated with mDCs were significantly higher in the ACS group than in control group. The proportion of pDCs was significantly lower in the ACS groups than in the other two groups. Interferon-α levels secreted by pDCs, however, were not significantly different among the 3 groups. The ratio of mDCs to pDCs ≥4 is an important value for distinguishing ACS from SAP patients and control patients through receiver operating characteristic analysis (sensitivity; 85.0%, specificity; 83.4%). Conclusions: The ratio of mDCs to pDCs may be a useful marker for detecting ACS and the existence of vulnerable plaques. (Circ J 2009; 73: 1914-1919)

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