Impact of Glycemic Control on the Clinical Outcome in Diabetic Patients With Percutaneous Coronary Intervention – From the FU-Registry –

Amane Ike; Hiroaki Nishikawa; Kazuyuki Shirai; Ken Mori; Takashi Kuwano; Yusuke Fukuda; Yosuke Takamiya; Daizaburo Yanagi; Kazumitsu Kubota; Yoshihiro Tsuchiya; Bo Zhang; Shin-ichiro Miura; Keijiro Saku

doi:10.1253/circj.CJ-10-0474

Late Breaking Clinical Trials (JCS 2011)

Impact of Glycemic Control on the Clinical Outcome in Diabetic Patients With Percutaneous Coronary Intervention

– From the FU-Registry –

Amane Ike, Hiroaki Nishikawa, Kazuyuki Shirai, Ken Mori, Takashi Kuwano, Yusuke Fukuda, Yosuke Takamiya, Daizaburo Yanagi, Kazumitsu Kubota, Yoshihiro Tsuchiya, Bo Zhang, Shin-ichiro Miura, Keijiro Saku

Author information

Amane Ike
Department of Cardiology, Fukuoka University School of Medicine
Hiroaki Nishikawa
Department of Cardiology, Fukuoka University School of Medicine
Kazuyuki Shirai
Department of Cardiology, Fukuoka University School of Medicine
Ken Mori
Department of Cardiology, Fukuoka University School of Medicine
Takashi Kuwano
Department of Cardiology, Fukuoka University School of Medicine
Yusuke Fukuda
Department of Cardiology, Fukuoka University School of Medicine
Yosuke Takamiya
Department of Cardiology, Fukuoka University School of Medicine
Daizaburo Yanagi
Department of Cardiology, Fukuoka University School of Medicine
Kazumitsu Kubota
Department of Cardiology, Fukuoka University School of Medicine
Yoshihiro Tsuchiya
Department of Cardiology, Fukuoka University School of Medicine
Bo Zhang
Department of Cardiology, Fukuoka University School of Medicine
Shin-ichiro Miura
Department of Cardiology, Fukuoka University School of Medicine
Keijiro Saku
Department of Cardiology, Fukuoka University School of Medicine

Keywords: Clinical outcome, Diabetes mellitus, Glycemic control, Percutaneous coronary intervention

JOURNAL FREE ACCESS

2011 Volume 75 Issue 4 Pages 791-799

DOI https://doi.org/10.1253/circj.CJ-10-0474

View "Advance Publication" version (March 18, 2011).

Details

Abstract

Background: It is not yet clear whether glycemic control affects the clinical outcome of percutaneous coronary intervention (PCI) in diabetic patients. Methods and Results: This study compared the effects of glycemic control on the clinical outcome in 2 groups of patients with diabetes mellitus (DM) who underwent PCI: a poor-glycemic-control group, who showed greater than 6.9% HbA_1c at the time of PCI (Pre-HbA_1c) (`≥6.9 group', n=334 patients) and a good-glycemic-control group, who showed less than <6.9% at Pre-HbA_1c (`<6.9 group', n=212 patients). The patients in the ≥6.9 group were further divided into 2 groups for further comparisons: a `DM control group' and a `Poor control group'. At follow-up (300 days), the incidence of major adverse cardiac event (MACE) was significantly (P<0.05) lower in the <6.9 group (18.4% vs. 26.2%). However, there was no difference in MACE between the DM control group and the Poor control group. In a multivariate analysis, there was no relationship between the incidence of MACE and Pre-HbA_1c, Pre-HbA_1c≥6.9% or the HbA_1c difference (Pre-HbA_1c-HbA_1c at follow-up). Conclusions: Clinical outcomes in the <6.9 group were superior to those in the ≥6.9 group as pre-PCI glycemic control affected the baseline characteristics. The results suggested that glycemic control started at PCI was not associated with an improvement in the clinical outcome at follow-up. (Circ J 2011; 75: 791-799)

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