Impaired Myocardial Perfusion Reserve in Patients With Fatty Liver Disease Assessed by Quantitative Myocardial Perfusion Magnetic Resonance Imaging

Shiro Nakamori; Katsuya Onishi; Hiroshi Nakajima; Yeonyee Elizabeth Yoon; Motonori Nagata; Tairo Kurita; Tomomi Yamada; Kakuya Kitagawa; Kaoru Dohi; Mashio Nakamura; Hajime Sakuma; Masaaki Ito

doi:10.1253/circj.CJ-11-1487

Metabolic Disorder

Impaired Myocardial Perfusion Reserve in Patients With Fatty Liver Disease Assessed by Quantitative Myocardial Perfusion Magnetic Resonance Imaging

Shiro Nakamori, Katsuya Onishi, Hiroshi Nakajima, Yeonyee Elizabeth Yoon, Motonori Nagata, Tairo Kurita, Tomomi Yamada, Kakuya Kitagawa, Kaoru Dohi, Mashio Nakamura, Hajime Sakuma, Masaaki Ito

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Shiro Nakamori
Department of Cardiology, Mie University Graduate School of Medicine
Katsuya Onishi
Department of Cardiology, Mie University Graduate School of Medicine
Hiroshi Nakajima
Department of Cardiology, Mie University Graduate School of Medicine
Yeonyee Elizabeth Yoon
Department of Radiology, Mie University Graduate School of Medicine
Motonori Nagata
Department of Radiology, Mie University Graduate School of Medicine
Tairo Kurita
Department of Cardiology, Mie University Graduate School of Medicine
Tomomi Yamada
Department of Translational Medical Science, Mie University Graduate School of Medicine
Kakuya Kitagawa
Department of Radiology, Mie University Graduate School of Medicine
Kaoru Dohi
Department of Cardiology, Mie University Graduate School of Medicine
Mashio Nakamura
Department of Cardiology, Mie University Graduate School of Medicine
Hajime Sakuma
Department of Radiology, Mie University Graduate School of Medicine
Masaaki Ito
Department of Cardiology, Mie University Graduate School of Medicine

Keywords: Abdominal computed tomography, Cardiac magnetic resonance, Fatty liver, Myocardial perfusion reserve

JOURNAL FREE ACCESS

2012 Volume 76 Issue 9 Pages 2234-2240

DOI https://doi.org/10.1253/circj.CJ-11-1487

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Abstract

Background: The purpose of this study was to determine whether the presence of fatty liver is associated with an alteration in myocardial perfusion reserve (MPR). Methods and Results: A retrospective analysis of 65 asymptomatic subjects who underwent both plain abdominal computed tomography and cardiac magnetic resonance imaging (MRI), and who had normal left ventricular wall motion, no regional myocardial ischemia and no myocardial scar on MRI was performed. Stress and rest myocardial perfusion MRI were analyzed by Patlak plot method to quantify myocardial blood flow (MBF) and MPR in 16 myocardial segments. Fatty liver was detected in 18 (28%) of the 65 subjects. No significant difference was found in rest-MBF between subjects with and without fatty liver (1.2±0.75 vs. 1.1±0.67ml·min^–1·g⁻¹, P=0.59). However, MPR was significantly lower in subjects with fatty liver than the non-fatty liver subjects (2.3±0.74 vs. 3.3±1.4, P<0.001). Subjects with fatty liver had a higher prevalence of MPR <2.5 (78% vs. 38%, P<0.005) and higher triglyceride levels (206±61 vs. 92±37mg/dl, P<0.001). Multivariate analysis revealed the presence of fatty liver as a significant predictor of reduced MPR with an odds ratio of 8.2 (P<0.01). Conclusions: Nonalcoholic fatty liver disease is related to reduced MPR, suggesting impaired coronary microcirculation. (Circ J 2012; 76: 2234–2240)

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