Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Vascular Biology and Vascular Medicine
Dipeptidyl Peptidase-4 Inhibitor, Sitagliptin, Improves Endothelial Dysfunction in Association With Its Anti-Inflammatory Effects in Patients With Coronary Artery Disease and Uncontrolled Diabetes
Junichi Matsubara, Seigo Sugiyama, Eiichi Akiyama, Satomi Iwashita, Hirofumi Kurokawa, Keisuke Ohba, Hirofumi Maeda, Koichiro Fujisue, Eiichiro Yamamoto, Koichi Kaikita, Seiji Hokimoto, Hideaki Jinnouchi, Hisao Ogawa
Author information
Keywords: Dipeptidyl peptidase-4 inhibitors, Endothelial function, Inflammation
JOURNAL FREE ACCESS

2013 Volume 77 Issue 5 Pages 1337-1344

Browse “Advance online publication” version
Details
Download PDF (994K)
Download citation RIS

(compatible with EndNote, Reference Manager, ProCite, RefWorks)

BIB TEX

(compatible with BibDesk, LaTeX)

Text
How to download citation
Contact us
Abstract

Background: Dipeptidyl peptidase 4 (DPP4) inhibitors are used for treatment of diabetes mellitus (DM). We hypothesized that sitagliptin, a DPP4-inhibitor, could improve endothelial dysfunction in DM patients with coronary artery disease (CAD). Methods and Results: The 40 patients with CAD and uncontrolled DM, aged 68.7±9.4 years (mean±standard deviation) (50% males, hemoglobin A1c [HbA1c] 7.4±1.0%) were assigned to either additional treatment with sitagliptin (50mg/day, n=20) or aggressive conventional treatment (control, n=20) for 6 months. Endothelial function was assessed by the reactive hyperemia peripheral arterial tonometry index (RHI). The clinical characteristics at baseline were not different between the groups. After treatment, fasting blood glucose and insulin levels, and lipid profiles were not different between the groups. HbA1c levels significantly improved similarly in both groups. The percent change in RHI was greater in the sitagliptin group than in the control group (62.4±59.2% vs. 15.9±22.0%, P<0.01). Furthermore, treatment with sitagliptin resulted in a significant decrease in the high-sensitivity C-reactive protein (hsCRP) level, but no such change was noted in the control group. Linear regression analysis demonstrated a significant negative relation between changes in RHI and hsCRP, but not between RHI and HbA1c. Conclusions: Sitagliptin significantly improved endothelial function and inflammatory state in patients with CAD and uncontrolled DM, beyond its hypoglycemic action. These findings suggest that sitagliptin has beneficial effects on the cardiovascular system in DM patients.  (Circ J 2013; 77: 1337–1344)

Content from these authors
© 2013 THE JAPANESE CIRCULATION SOCIETY
Previous article Next article
Favorites & Alerts

Recently viewed articles
Predecessor

The Nippon Journal of Clinical Angio-Cardiology

Japanese Circulation Journal

JAPANESE CIRCULATION JOURNAL

Related information

Request a Permission

Related journals
Circulation Reports
Share this page
feedback
 Top