Vascular Response to Drug-Eluting Stent With Biodegradable vs. Durable Polymer – Optical Coherence Tomography Substudy of the NEXT –

Takashi Kubo; Takashi Akasaka; Ken Kozuma; Kazuo Kimura; Tetsuya Fusazaki; Hiroyuki Okura; Toshiro Shinke; Yasushi Ino; Takao Hasegawa; Hiroaki Takashima; Itaru Takamisawa; Hiroshi Yamaguchi; Keiichi Igarashi; Kazushige Kadota; Kengo Tanabe; Yoshihisa Nakagawa; Toshiya Muramatsu; Yoshihiro Morino; Takeshi Kimura; on behalf of the NEXT Investigators

doi:10.1253/circj.CJ-14-0337

Cardiovascular Intervention

Vascular Response to Drug-Eluting Stent With Biodegradable vs. Durable Polymer

– Optical Coherence Tomography Substudy of the NEXT –

Takashi Kubo, Takashi Akasaka, Ken Kozuma, Kazuo Kimura, Tetsuya Fusazaki, Hiroyuki Okura, Toshiro Shinke, Yasushi Ino, Takao Hasegawa, Hiroaki Takashima, Itaru Takamisawa, Hiroshi Yamaguchi, Keiichi Igarashi, Kazushige Kadota, Kengo Tanabe, Yoshihisa Nakagawa, Toshiya Muramatsu, Yoshihiro Morino, Takeshi Kimura, on behalf of the NEXT Investigators

Author information

Takashi Kubo
Department of Cardiovascular Medicine, Wakayama Medical University
Takashi Akasaka
Department of Cardiovascular Medicine, Wakayama Medical University
Ken Kozuma
Division of Cardiology, Teikyo University Hospital
Kazuo Kimura
Division of Cardiology, Yokohama City University Medical Center
Tetsuya Fusazaki
Division of Cardiology, Iwate Medical University
Hiroyuki Okura
Division of Cardiology, Kawasaki Medical School
Toshiro Shinke
Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine
Yasushi Ino
Department of Cardiovascular Medicine, Wakayama Medical University
Takao Hasegawa
Division of Cardiovascular Medicine, Osaka City University Hospital
Hiroaki Takashima
Department of Cardiology, Aichi Medical University Hospital
Itaru Takamisawa
Division of Cardiology, Sakakibara Memorial Hospital
Hiroshi Yamaguchi
Division of Cardiology, Tenyoukai Central Hospital
Keiichi Igarashi
Division of Cardiology, Hokkaido Social Insurance Hospital
Kazushige Kadota
Division of Cardiology, Kurashiki Central Hospital
Kengo Tanabe
Division of Cardiology, Mitsui Memorial Hospital
Yoshihisa Nakagawa
Division of Cardiology, Tenri Hospital
Toshiya Muramatsu
Division of Cardiology, Saiseikai Yokohamashi Tobu Hospital
Yoshihiro Morino
Division of Cardiology, Iwate Medical University
Takeshi Kimura
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
on behalf of the NEXT Investigators

Keywords: Drug-eluting stent, Optical coherence tomography, Percutaneous coronary intervention

JOURNAL FREE ACCESS FULL-TEXT HTML

2014 Volume 78 Issue 10 Pages 2408-2414

DOI https://doi.org/10.1253/circj.CJ-14-0337

Editorial (78-10 pp.2376-2377)

Browse “Advance online publication” version

Details

Abstract

Background:The aim of the present study was to compare vascular healing response between everolimus-eluting stent (EES) and biolimus-eluting stent (BES) using optical coherence tomography (OCT).Methods and Results:In the NOBORI Biolimus-Eluting Versus XIENCE V/PROMUS Everolimus-Eluting Stent Trial (NEXT), a formal OCT substudy investigated 91 patients (55 EES-treated lesions in 48 patients and 51 BES-treated lesions in 43 patients) with 8–12 months follow-up imaging at 18 centers. A total of 980 frames with 8,996 struts in EES and 907 frames with 8,745 struts in BES were analyzed. Mean neointima thickness in EES and BES was 105±82μm and 91±80μm, respectively (P<0.001). With regard to stent-treated lesions, the percentage of struts not covered by neointima (3±7% vs. 9±10%, P<0.001) and the frequency of stent-treated lesions with any uncovered struts (n=28, 51% vs. n=42, 82%; P<0.001) were significantly lower in EES compared with BES. In addition, the percentage of malapposed struts (0.2±0.8% vs. 1.3±2.8%, P=0.006) and the frequency of stent-treated lesions with any malapposed struts (n=6, 11% vs. n=14, 27%; P=0.028) were significantly lower in EES compared with BES.Conclusions:Incomplete vascular healing characterized by the presence of struts not covered by neointima and malapposed struts was less common in EES compared with BES. (Circ J 2014; 78: 2408–2414)

Corresponding author

Register with J-STAGE for free!