Plasma MicroRNA-100 Is Associated With Coronary Plaque Vulnerability

Takeshi Soeki; Koji Yamaguchi; Toshiyuki Niki; Etsuko Uematsu; Sachiko Bando; Tomomi Matsuura; Takayuki Ise; Kenya Kusunose; Junko Hotchi; Takeshi Tobiume; Shusuke Yagi; Daiju Fukuda; Yoshio Taketani; Takashi Iwase; Hirotsugu Yamada; Tetsuzo Wakatsuki; Michio Shimabukuro; Masataka Sata

doi:10.1253/circj.CJ-14-0958

Ischemic Heart Disease

Plasma MicroRNA-100 Is Associated With Coronary Plaque Vulnerability

Takeshi Soeki, Koji Yamaguchi, Toshiyuki Niki, Etsuko Uematsu, Sachiko Bando, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Junko Hotchi, Takeshi Tobiume, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Masataka Sata

Author information

Takeshi Soeki
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Koji Yamaguchi
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Toshiyuki Niki
Department of Cardiovascular Medicine, Shikoku Medical Center for Children and Adults
Etsuko Uematsu
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Sachiko Bando
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Tomomi Matsuura
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Takayuki Ise
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Kenya Kusunose
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Junko Hotchi
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Takeshi Tobiume
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Shusuke Yagi
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Daiju Fukuda
Department of Cardio-Diabetes Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Yoshio Taketani
Department of Cardiovascular Medicine, Shikoku Medical Center for Children and Adults
Takashi Iwase
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Hirotsugu Yamada
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Tetsuzo Wakatsuki
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Michio Shimabukuro
Department of Cardio-Diabetes Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
Masataka Sata
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School

Keywords: Coronary artery disease, Coronary circulation, Intravascular ultrasound, MicroRNA

JOURNAL FREE ACCESS FULL-TEXT HTML

2015 Volume 79 Issue 2 Pages 413-418

DOI https://doi.org/10.1253/circj.CJ-14-0958

Editorial (79-2 pp.303-304)

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Abstract

Background:Although numerous studies have reported altered plasma levels of various microRNAs (miRNAs) in patients with cardiovascular disease, there are no data on the relationship between plasma miRNAs and vulnerable coronary plaque. In this study, we investigated whether plasma miRNAs might be a sensitive marker of coronary plaque vulnerability.Methods and Results:Integrated backscatter intravascular ultrasound (IB-IVUS) was performed in 32 consecutive patients with angina pectoris who underwent percutaneous coronary intervention. Three-dimensional analysis of IB-IVUS was performed to determine the percentage of lipid volume (%LV) and fibrous volume (%FV). Circulating miRNAs were measured in EDTA-plasma simultaneously obtained from the aorta and the coronary sinus (CS). Muscle-enriched (miR-133a, miR-208a, miR-499), vascular-enriched (miR-92a, miR-100, miR-126, miR-127, miR-145), and myeloid cell-enriched miRNAs (miR-155, miR-223) were measured. Plasma miR-100 was higher in the CS than in the aorta, but there were no significant differences in the levels of other miRNAs between the aorta and CS. Plasma miR-100 in the aorta was positively correlated with %LV (r=0.48, P<0.01) and negatively correlated with %FV (r=–0.41, P<0.05). Importantly, transcoronary concentration gradient of circulating miR-100 was more strongly correlated with %LV (r=0.53, P<0.01) and %FV (r=–0.56, P<0.01).Conclusions:miR-100 might be released into the coronary circulation from vulnerable coronary plaques. This study provides insights into the role of miRNAs in coronary atherosclerotic disease. (Circ J 2015; 79: 413–418)

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