Left Ventricular Global Strain for Estimating Relaxation and Filling Pressure　– A Multicenter Study –

Taichi Hayashi; Satoshi Yamada; Hiroyuki Iwano; Masahiro Nakabachi; Mamoru Sakakibara; Kazunori Okada; Daisuke Murai; Hisao Nishino; Kenya Kusunose; Kiyotaka Watanabe; Tomoko Ishizu; Kazuaki Wakami; Hirotsugu Yamada; Kaoru Dohi; Yoshihiro Seo; Nobuyuki Ohte; Taisei Mikami; Hiroyuki Tsutsui

doi:10.1253/circj.CJ-16-0106

Heart Failure

Left Ventricular Global Strain for Estimating Relaxation and Filling Pressure　– A Multicenter Study –

Taichi Hayashi, Satoshi Yamada, Hiroyuki Iwano, Masahiro Nakabachi, Mamoru Sakakibara, Kazunori Okada, Daisuke Murai, Hisao Nishino, Kenya Kusunose, Kiyotaka Watanabe, Tomoko Ishizu, Kazuaki Wakami, Hirotsugu Yamada, Kaoru Dohi, Yoshihiro Seo, Nobuyuki Ohte, Taisei Mikami, Hiroyuki Tsutsui

Author information

Taichi Hayashi
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
Satoshi Yamada
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
Hiroyuki Iwano
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
Masahiro Nakabachi
Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
Mamoru Sakakibara
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
Kazunori Okada
Faculty of Health Sciences, Hokkaido University
Daisuke Murai
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
Hisao Nishino
Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
Kenya Kusunose
Department of Cardiovascular Medicine, Tokushima University Hospital
Kiyotaka Watanabe
Department of Cardiology and Nephrology, Mie University Graduate School of Medicine
Tomoko Ishizu
Cardiovascular Division, Faculty of Medicine, University of Tsukuba
Kazuaki Wakami
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences
Hirotsugu Yamada
Department of Cardiovascular Medicine, Tokushima University Hospital
Kaoru Dohi
Department of Cardiology and Nephrology, Mie University Graduate School of Medicine
Yoshihiro Seo
Cardiovascular Division, Faculty of Medicine, University of Tsukuba
Nobuyuki Ohte
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences
Taisei Mikami
Faculty of Health Sciences, Hokkaido University
Hiroyuki Tsutsui
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

Keywords: Diastolic dysfunction, Heart diseases, Heart failure, Speckle-tracking echocardiography

JOURNAL FREE ACCESS FULL-TEXT HTML

2016 Volume 80 Issue 5 Pages 1163-1170

DOI https://doi.org/10.1253/circj.CJ-16-0106

Editorial (80-5 pp. 1104-1105)

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Abstract

Background:Speckle-tracking echocardiography (STE)-derived parameters may have better correlation with left ventricular (LV) relaxation and filling pressure than tissue Doppler-derived parameters. However, it has not been elucidated which parameter – strain or strain rate – and which direction of myocardial deformation – longitudinal or circumferential – is the most useful marker of LV relaxation and filling pressure.Methods and Results:We conducted a prospective multicenter study and compared the correlation of tissue Doppler- and STE-derived parameters with the time constant of LV pressure decay (τ) and LV mean diastolic pressure (MDP) in 77 patients. The correlation of early-diastolic mitral annular velocity (e´) with τ was weak (r=−0.32, P<0.01), and that of peak longitudinal strain (LS) was the strongest (r=−0.45, P<0.001) among the STE-derived parameters. There was a modest correlation between LVMDP and the ratio of early-diastolic inflow velocity (E) to e´ (E/e´) (r=0.50, P<0.001). In contrast, the ratio of E to LS (E/LS) correlated strongly with LVMDP (r=0.70, P<0.001). The correlation of E/LS with LVMDP was significantly better than that for E/e´ (P<0.01). Receiver-operating characteristic analysis showed that E/LS had the largest area under the curve for distinguishing elevated LVMDP (E/LS 0.86, E/e´ 0.74, E/A 0.67).Conclusions:STE-derived longitudinal parameters correlated well with LV relaxation and filling pressure. In particular, E/LS could be more accurate than E/e´ for estimating LV filling pressure. (Circ J 2016; 80: 1163–1170)

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