Focal Reduction in Cardiac 123I-Metaiodobenzylguanidine Uptake in Patients With Anderson-Fabry Disease

Saori Yamamoto; Hideaki Suzuki; Koichiro Sugimura; Shunsuke Tatebe; Tatsuo Aoki; Masanobu Miura; Nobuhiro Yaoita; Haruka Sato; Katuya Kozu; Hideki Ota; Kentaro Takanami; Kei Takase; Hiroaki Shimokawa

doi:10.1253/circj.CJ-16-0690

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Focal Reduction in Cardiac ¹²³I-Metaiodobenzylguanidine Uptake in Patients With Anderson-Fabry Disease

Saori Yamamoto, Hideaki Suzuki, Koichiro Sugimura, Shunsuke Tatebe, Tatsuo Aoki, Masanobu Miura, Nobuhiro Yaoita, Haruka Sato, Katuya Kozu, Hideki Ota, Kentaro Takanami, Kei Takase, Hiroaki Shimokawa

Author information

Saori Yamamoto
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Hideaki Suzuki
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Koichiro Sugimura
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Shunsuke Tatebe
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Tatsuo Aoki
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Masanobu Miura
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Nobuhiro Yaoita
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Haruka Sato
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Katuya Kozu
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Hideki Ota
Department of Radiology, Tohoku University Graduate School of Medicine
Kentaro Takanami
Department of Radiology, Tohoku University Graduate School of Medicine
Kei Takase
Department of Radiology, Tohoku University Graduate School of Medicine
Hiroaki Shimokawa
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

Keywords: Anderson-Fabry disease, Cardiomyopathy, Cardiovascular magnetic resonance, MIBG scintigraphy

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Supplementary material

2016 Volume 80 Issue 12 Pages 2550-2551

DOI https://doi.org/10.1253/circj.CJ-16-0690

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Abstract

Background:It remains to be elucidated whether cardiac sympathetic nervous activity is impaired in patients with Anderson-Fabry disease (AFD).

Methods and Results:We performed ¹²³I-meta-iodobenzylguanidine (MIBG) scintigraphy and gadolinium-enhanced cardiovascular magnetic resonance (CMR) in 5 AFD patients. MIBG uptake in the inferolateral wall, where wall thinning and delayed enhancement were noted on CMR, was significantly lower compared with the anteroseptal wall. The localized reduction in MIBG uptake was also noted in 2 patients with no obvious abnormal findings on CMR.

Conclusions:Cardiac sympathetic nervous activity is impaired in AFD before development of structural myocardial abnormalities. (Circ J 2016; 80: 2550–2551)

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