Life Style-Related Diseases of the Digestive System:  Colorectal Cancer as a Life Style-Related Disease: from Carcinogenesis to Medical Treatment

Hirokazu Takahashi; Kyoko Yoneda; Ayako Tomimoto; Hiroki Endo; Toshio Fujisawa; Hiroshi Iida; Hironori Mawatari; Yuichi Nozaki; Tamon Ikeda; Tomoyuki Akiyama; Masato Yoneda; Masahiko Inamori; Yasunobu Abe; Satoru Saito; Atsushi Nakajima; Hitoshi Nakagama

doi:10.1254/jphs.FM0070022

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Life Style-Related Diseases of the Digestive System:
Colorectal Cancer as a Life Style-Related Disease: from Carcinogenesis to Medical Treatment

Hirokazu Takahashi, Kyoko Yoneda, Ayako Tomimoto, Hiroki Endo, Toshio Fujisawa, Hiroshi Iida, Hironori Mawatari, Yuichi Nozaki, Tamon Ikeda, Tomoyuki Akiyama, Masato Yoneda, Masahiko Inamori, Yasunobu Abe, Satoru Saito, Atsushi Nakajima, Hitoshi Nakagama

Author information

Hirokazu Takahashi
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Kyoko Yoneda
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Ayako Tomimoto
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Hiroki Endo
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Toshio Fujisawa
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Hiroshi Iida
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Hironori Mawatari
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Yuichi Nozaki
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Tamon Ikeda
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Tomoyuki Akiyama
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Masato Yoneda
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Masahiko Inamori
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Yasunobu Abe
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Satoru Saito
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Atsushi Nakajima
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
Hitoshi Nakagama
Biochemistry Division, National Cancer Center Research Institute, Japan

Keywords: life style-related disease, colorectal cancer, chemoprevention, aberrant crypt foci (ACF), peroxisome proliferator-activated receptor gamma (PPARγ)

JOURNAL FREE ACCESS

2007 Volume 105 Issue 2 Pages 129-132

DOI https://doi.org/10.1254/jphs.FM0070022

View "Advance Publication" version (October 6, 2007).

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Abstract

Life style-related diseases are associated with an increased risk of colorectal cancer (CRC). Recently, an association has been demonstrated between obesity and CRC. CRC has been associated with markers of insulin or glucose control, and insulin resistance might be the unifying mechanism by which several risk factors affect colorectal carcinogenesis. We evaluated the association between the number of aberrant crypt foci (ACF) and obesity, insulin resistance, hyperlipidemia, and other factors of life style-related disease. As a result, age, body mass index (BMI), waist circumference, and visceral fat obesity were significantly associated with the number of ACF. These results suggest that visceral fat obesity is an important target for CRC prevention. Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor superfamily and is highly expressed in CRC. PPARγ ligand administration for 1 to 8 months significantly reduced the number of ACF in human subjects. PPARγ ligand is a promising candidate as a chemopreventive agent. Further investigation is needed to elucidate these mechanisms.

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