Effect of Quetiapine on Per1, Per2, and Bmal1 Clock Gene Expression in the Mouse Amygdala and Hippocampus

Shunpei Moriya; Yu Tahara; Hiroyuki Sasaki; Yutaro Hamaguchi; Daisuke Kuriki; Ryosuke Ishikawa; Jun Ishigooka; Shigenobu Shibata

doi:10.1254/jphs.14071SC

Short Communication

Effect of Quetiapine on Per1, Per2, and Bmal1 Clock Gene Expression in the Mouse Amygdala and Hippocampus

Shunpei Moriya, Yu Tahara, Hiroyuki Sasaki, Yutaro Hamaguchi, Daisuke Kuriki, Ryosuke Ishikawa, Jun Ishigooka, Shigenobu Shibata

Author information

Shunpei Moriya
Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
Department of Psychiatry, Tokyo Women’s Medical University, School of Medicine, Japan
Yu Tahara
Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
Hiroyuki Sasaki
Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
Yutaro Hamaguchi
Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
Daisuke Kuriki
Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
Ryosuke Ishikawa
Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
Jun Ishigooka
Department of Psychiatry, Tokyo Women’s Medical University, School of Medicine, Japan
Shigenobu Shibata
Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan

Keywords: quetiapine, clock gene, depression

JOURNAL FREE ACCESS

2014 Volume 125 Issue 3 Pages 329-332

DOI https://doi.org/10.1254/jphs.14071SC

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Abstract

Circadian rhythms are related to various psychiatric disorders. Recently, antipsychotics, including quetiapine (QTP), have been accepted as potential therapeutic agents for the treatment of depression, but its mechanism remains poorly understood. In this study, we examined clock gene fluctuation patterns in QTP-treated mice. QTP significantly increased Per2 mRNA at ZT12 and Per1 and Per2 expression at ZT18 in the amygdala. There were significant differences between the control and QTP groups in the cross-time effects of Per2 mRNA expression in the amygdala. Our findings suggest that QTP possibly acts on the circadian system, which then induces changes in mood symptoms.

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