Mechanical Hypersensitivity and Alterations in Cutaneous Nerve Fibers in a Mouse Model of Skin Cancer Pain

Hong-Wei Zhang; Yuko Iida; Tsugunobu Andoh; Hiroshi Nojima; Jun Murata; Ikuo Saiki; Yasushi Kuraishi

doi:10.1254/jphs.91.167

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Mechanical Hypersensitivity and Alterations in Cutaneous Nerve Fibers in a Mouse Model of Skin Cancer Pain

Hong-Wei Zhang, Yuko Iida, Tsugunobu Andoh, Hiroshi Nojima, Jun Murata, Ikuo Saiki, Yasushi Kuraishi

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Keywords: skin cancer pain, primary afferent fiber, allodynia and hyperalgesia

JOURNAL FREE ACCESS

2003 Volume 91 Issue 2 Pages 167-170

DOI https://doi.org/10.1254/jphs.91.167

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Abstract

Melanoma inoculation induced marked mechanical allodynia and hyperalgesia in the periphery of the melanoma mass in mice from about day 10 post-inoculation. In the middle of the tumor, there were slight hyperalgesia and response disappearance in the early and late phases, respectively. PGP9.5-like immunoreactivities increased in the epidermis of the periphery of the tumor and disappeared from the dermis of the middle on day 18 post-inoculation, without apparent alterations on day 10. When using this pain model, one should consider the tumor site-dependent responses.

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