Acute Protective Effects of Simvastatin in the Rat Model of Renal Ischemia-Reperfusion Injury: It Is Never Too Late for the Pretreatment

Zoran Todorovic; Zorica Nesic; Radan Stojanovic; Gordana Basta-Jovanovic; Sanja Radojevic-Skodric; Ruzca Velickovic; Prabal K. Chatterjee; Christoph Thiemermann; Milica Prostran

doi:10.1254/jphs.SC0070374

Short Communications

Acute Protective Effects of Simvastatin in the Rat Model of Renal Ischemia-Reperfusion Injury: It Is Never Too Late for the Pretreatment

Zoran Todorovic, Zorica Nesic ^†, Radan Stojanovic, Gordana Basta-Jovanovic, Sanja Radojevic-Skodric ^†, Ruzca Velickovic, Prabal K. Chatterjee, Christoph Thiemermann, Milica Prostran

Author information

Zoran Todorovic
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Serbia
Zorica Nesic ^†
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Serbia
Radan Stojanovic
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Serbia
Gordana Basta-Jovanovic
Department of Pathology, School of Medicine, University of Belgrade, Serbia
Sanja Radojevic-Skodric ^†
Department of Pathology, School of Medicine, University of Belgrade, Serbia
Ruzca Velickovic
Institute of Mental Health, Laboratory of Biochemistry, Serbia
Prabal K. Chatterjee
School of Pharmacy & Biomolecular Sciences, University of Brighton, United Kingdom
Christoph Thiemermann
The William Harvey Research Institute, St. Bartholomew’s and Royal London School of Medicine and Dentistry, United Kingdom
Milica Prostran
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Serbia
Author contributions

†These authors contributed equally: Zorica Nesic, Sanja Radojevic-Skodric

Keywords: simvastatin, acute pretreatment, ischemia-reperfusion (I/R) renal injury

JOURNAL FREE ACCESS

2008 Volume 107 Issue 4 Pages 465-470

DOI https://doi.org/10.1254/jphs.SC0070374

Details

Abstract

Acute pretreatment with a single i.v. bolus injection of simvastatin (1 mg/kg) significantly protects rat kidney injured by ischemia-reperfusion (I/R) (45 min + 6 h). We aimed to determine the optimal timing of such a pretreatment. The effects of both injections of simvastatin before ischemia and reperfusion were similar regarding total histological score. However, simvastatin injected 30 min before ischemia was 30% – 75% more effective in reduction of serum creatinine levels and interstitial edema score, while its injections 5 and 30 min before reperfusion were 25% – 60% more effective in reduction of tubular necrosis score and fractional excretion of Na⁺. However, the observed differences do not seem to offer significant advantage in clinical settings.

Corresponding author

Register with J-STAGE for free!